Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/106771
Título: Oncological outcomes of lipofilling in breast reconstruction: a matched cohort study with 250 patients
Autores/as: Casarrubios, Jose M.
Francés, Monica 
Fuertes, Victor
Singer, Margit
Navarro, Carlos
García-Duque, Orlando
Fernández-Palacios, Javier
Clasificación UNESCO: 320101 Oncología
Palabras clave: Breast Cancer
Breast Reconstruction
Fat Grafting
Lipofilling
Oncological Safety
Fecha de publicación: 2021
Publicación seriada: Gland Surgery 
Resumen: Background: Fat grafting is a procedure commonly used in breast reconstruction nowadays. Nevertheless, its oncological safety remains controversial. The potential risk that progenitor cells included in fat graft tissue may contribute to disease progression in patients with breast cancer is still debatable. We have designed a matchingcohort study with 250 patients with history of breast cancer trying to elucidate an answer for this question. Methods: We selected 250 patients with a history of breast cancer in our hospital, between 2011 and 2019. A total of 125 patients (cases) had a history of breast cancer reconstructed with fat grafting. The additional 125 patients are matched controls. We analyzed the distribution of eight different variables within the cases and their matched controls: date of first oncological surgery, age, type of oncological surgery, histological subtype, Her-2 status, pN, smoking habit and diabetes mellitus. The objective of this study was to analyze the influence of fat grafting over breast cancer recurrence. Results: There are not statistically significant differences in breast cancer locoregional recurrences (P=0.183), distant metastases (P=0.200) or total recurrences (P=0.065) amongst the two groups (cancer cases and matched controls). Conclusions: Our study adds more information over the oncological safety of fat grafting. These findings should encourage long-term prospective trials to provide surgeons with accurate information regarding the role of lipofilling on breast neoplasms.
URI: http://hdl.handle.net/10553/106771
ISSN: 2227-684X
DOI: 10.21037/gs-20-775
Fuente: Gland Surgery [ISSN 2227-684X],v. 10 (3), p. 914-923, (Enero 2021)
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