Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/55352
DC FieldValueLanguage
dc.contributor.authorQuintana, José-
dc.contributor.authorEstévez, Francisco-
dc.date.accessioned2019-04-30T10:27:28Z-
dc.date.available2019-04-30T10:27:28Z-
dc.date.issued2018-
dc.identifier.issn1381-6128-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/55352-
dc.description.abstractSesquiterpene lactones are naturally occurring compounds that have attracted considerable attention because to their vast array of biological activities. These plant-derived compounds contain the α-methylene-γ- butyrolactone functional group, which is the structural requirement for their pharmacological activities. Many of them exhibit cancer cell cytotoxicity and are promising anticancer agents through multiple mechanisms of action. Sesquiterpene lactones are alkylating agents that form covalent adducts in vivo and inhibit enzymes and key proteins. They are also potent apoptotic inducers in several cancer cells. This kind of cell death is recognized as a property that is useful for identifying anticancer drugs. This review focuses on the advances on cytotoxic sesquiterpene lactones and specifically the signal transduction pathways of cell death triggered in cancer cells.-
dc.languageeng-
dc.relation.ispartofCurrent Pharmaceutical Design-
dc.sourceCurrent Pharmaceutical Design [ISSN 1381-6128], v. 24 (36), p. 4355 - 4361-
dc.subject2302 Bioquímica-
dc.subject2407 Biología celular-
dc.subject.otherSesquiterpene lactones-
dc.subject.otherApoptosis-
dc.subject.otherCaspases-
dc.subject.otherCytotoxicity-
dc.subject.otherCell death-
dc.subject.otherCell cycle arrest-
dc.subject.otherMitogen-activated protein kinases-
dc.subject.otherReactive oxygen species-
dc.titleRecent Advances on Cytotoxic Sesquiterpene Lactones-
dc.typeinfo:eu-repo/semantics/review-
dc.typeReview-
dc.identifier.doi10.2174/1381612825666190119114323-
dc.identifier.scopus85063678128-
dc.identifier.isi000458726500008-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.identifier.eissn1873-4286-
dc.description.lastpage4361-
dc.identifier.issue36-
dc.description.firstpage4355-
dc.relation.volume24-
dc.investigacionCiencias de la Salud-
dc.type2Reseña-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.description.numberofpages7-
dc.utils.revision-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdate2018-
dc.identifier.ulpgc-
dc.contributor.buulpgcBU-MED-
dc.description.sjr0,703
dc.description.jcr2,412
dc.description.sjrqQ2
dc.description.jcrqQ3
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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