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Title: R5020 Enhances Pge2 Stimulated Steroidogenesis In Cultured Rat Granulosa-Cells
Authors: Fanjul, Lf
Gonzalez, J
Santana, P
Estevez, F 
Quintana, J 
Degalarreta, Cmr
Keywords: Human Chorionic-Gonadotropin
Progesterone Production
Preovulatory Follicles
Luteinizing-Hormone, et al
Issue Date: 1992
Publisher: 0034-9402
Journal: Revista Espanola de Fisiologia 
Abstract: Progesterone biosynthesis and metabolization to 20alpha-hydroxyprogesterone was stimulated in granulosa cells cultured in the presence of 20 ng/ml of follicle stimulating hormone (FSH) or increasing concentrations of PGE2 (10(-9)-10(-7) M). Concurrent treatment with the synthetic progestin R5020 (10(-6) M) enhanced the FSH or PGE2 stimulated progesterone and 20alpha-hydroxyprogesterone accumulation in culture media, as well as DELTA5-3beta-hydroxysteroid dehydrogenase activity in granulosa cell homogenates. These findings may represent another example of an autocrine control mechanism in which the steroidogenic product of the granulosa cell exerts an ultra-short loop regulation of its own production.
ISSN: 0034-9402
Source: Revista Espanola De Fisiologia[ISSN 0034-9402],v. 48 (3), p. 167-170
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