|Title:||R5020 Enhances Pge2 Stimulated Steroidogenesis In Cultured Rat Granulosa-Cells||Authors:||Fanjul, Lf
Luteinizing-Hormone, et al
|Issue Date:||1992||Publisher:||0034-9402||Journal:||Revista Espanola de Fisiologia||Abstract:||Progesterone biosynthesis and metabolization to 20alpha-hydroxyprogesterone was stimulated in granulosa cells cultured in the presence of 20 ng/ml of follicle stimulating hormone (FSH) or increasing concentrations of PGE2 (10(-9)-10(-7) M). Concurrent treatment with the synthetic progestin R5020 (10(-6) M) enhanced the FSH or PGE2 stimulated progesterone and 20alpha-hydroxyprogesterone accumulation in culture media, as well as DELTA5-3beta-hydroxysteroid dehydrogenase activity in granulosa cell homogenates. These findings may represent another example of an autocrine control mechanism in which the steroidogenic product of the granulosa cell exerts an ultra-short loop regulation of its own production.||URI:||http://hdl.handle.net/10553/53517||ISSN:||0034-9402||Source:||Revista Espanola De Fisiologia[ISSN 0034-9402],v. 48 (3), p. 167-170|
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