Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50584
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dc.contributor.authorFanjul, Luisa F.
dc.contributor.authorDéniz, Antonio
dc.contributor.authorQuintana, José
dc.contributor.authorSantana, Pino
dc.contributor.authorGonzalez, Juan
dc.contributor.authorEstevez, Francisco
dc.contributor.authorRuiz de Galarreta, Carlos M.
dc.date.accessioned2018-11-24T17:11:31Z-
dc.date.available2018-11-24T17:11:31Z-
dc.date.issued1992
dc.identifier.issn0006-291X
dc.identifier.urihttp://hdl.handle.net/10553/50584-
dc.description.abstractTreatment of cultured granulosa cells with PLC or GnRH stimulated the rapid generation of DAG and phosphoinositide turnover. The PKC activators PLC (3 mU/ml) and TPA (10-7M) or the decapeptide GnRH (10-6M) elicited similar inhibitory responses on FSH or cAMP stimulated granulosa cell steroidogenesis. Mobilization of intracellular Ca2+ with A23187 (10-8M) was followed by a slight increase in the steroidogenic activity of cultured granulosa cells, whereas elevation of extracellular K+ (50 mM) largely augmented the steroid biosynthetic activity of the granulosa cells. These results suggest that the inhibitory effect of GnRH on granulosa cell steroidogenesis is mediated by generation of DAG, rather than by increases in intracellular Ca2+ concentrations. © 1992.
dc.publisher0006-291X
dc.relation.ispartofBiochemical and biophysical research communications (Print)
dc.sourceBiochemical and Biophysical Research Communications[ISSN 0006-291X],v. 188, p. 198-204
dc.titleDiacylglycerol rather than Ca<sup>2+</sup> mediates GnRH inhibition of FSH induced steroidogenesis in ovarian granulosa cells
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/0006-291X(92)92369-9
dc.identifier.scopus0026613759
dc.contributor.authorscopusid7004158812
dc.contributor.authorscopusid7004186223
dc.contributor.authorscopusid7004186223
dc.contributor.authorscopusid8681043500
dc.contributor.authorscopusid7003526778
dc.contributor.authorscopusid57198495832
dc.contributor.authorscopusid7003810011
dc.contributor.authorscopusid7003806034
dc.description.lastpage204
dc.description.firstpage198
dc.relation.volume188
dc.type2Artículoes
dc.date.coverdateOctubre 1992
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptSeñalización Intracelular y Expresión Génica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFanjul Rodríguez, Luisa Fernanda-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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