Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/46622
Campo DC Valoridioma
dc.contributor.authorRodríguez de Castro, Felipeen_US
dc.contributor.authorTorres, Antonien_US
dc.date.accessioned2018-11-23T06:28:21Z-
dc.date.available2018-11-23T06:28:21Z-
dc.date.issued2003en_US
dc.identifier.issn1175-6365en_US
dc.identifier.urihttp://hdl.handle.net/10553/46622-
dc.description.abstractSevere community-acquired pneumonia (CAP) is a life-threatening condition that requires intensive care unit (ICU) admission. Clinical presentation is characterized by the presence of respiratory failure, severe sepsis, or septic shock. Severe CAP accounts for approximately 5-35% of hospital-treated cases of pneumonia with the majority of patients having underlying comorbidities. The most common pathogens associated with this disease are Streptococcus pneumoniae, Legionella spp., Haemophilus influenzae, and Gram-negative enteric rods. Microbial investigation is probably helpful in the individual case but is likely to be more useful for defining local antimicrobial policies. The early and rapid initiation of empiric antimicrobial treatment is critical for a favorable outcome. It should include intravenous β-lactam along with either a macrolide or a fluoroquinolone. Modifications of this basic regimen should be considered in the presence of distinct comorbid conditions and risk factors for specific pathogens. Other promising nonantimicrobial new therapies are currently being investigated. The assessment of severity of CAP helps physicians to identify patients who could be managed safely in an ambulatory setting. It may also play a crucial role in decisions about length of hospital stay and time of switching to oral antimicrobial therapy in different groups at risk. The most important adverse prognostic factors include advancing age, male sex, poor health of patient, acute respiratory failure, severe sepsis, septic shock, progressive radiographic course, bacteremia, signs of disease progression within the first 48-72 hours, and the presence of several different pathogens such as S. pneumoniae, Staphylococcus aureus, Gram-negative enteric bacilli, or Pseudomonas aeruginosa. However, some important topics of severity assessment remain controversial, including the definition of severe CAP. Prediction rules for complications or death from CAP, although far from perfect, should identify the majority of patients with severe CAP and be used to support decision-making by the physician. They may also contribute to the evaluation of processes and outcomes of care for patients with CAP.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Respiratory Medicineen_US
dc.sourceAmerican Journal of Respiratory Medicine [ISSN 1175-6365], v. 2, p. 39-54en_US
dc.subject32 Ciencias médicasen_US
dc.subject320505 Enfermedades infecciosasen_US
dc.subject320508 Enfermedades pulmonaresen_US
dc.subject.otherPneumoniaen_US
dc.subject.otherTreatmenten_US
dc.subject.otherRespiratory diseaseen_US
dc.titleOptimizing treatment outcomes in severe community-acquired pneumoniaen_US
dc.typeinfo:eu-repo/semantics/reviewen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/BF03256638en_US
dc.identifier.scopus0041854731-
dc.contributor.authorscopusid55942667000-
dc.contributor.authorscopusid56714659000-
dc.description.lastpage54en_US
dc.description.firstpage39en_US
dc.relation.volume2en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Reseñaen_US
dc.description.numberofpages16en_US
dc.utils.revisionen_US
dc.date.coverdateEnero 2003en_US
dc.identifier.ulpgcen_US
dc.identifier.ulpgcen_US
dc.identifier.ulpgcen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Patología y Tecnología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-6812-2739-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
Colección:Reseña
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