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Title: Immune response in goats vaccinated with thiol-binding proteins from Haemonchus contortus
Authors: Molina Caballero, José Manuel 
Hernández Ortega,Yeray 
Martín Martel, Sergio 
Ferrer Quintana, Otilia Rosa 
Rodríguez Guisado, Francisco 
Ruiz Reyes, Antonio 
UNESCO Clasification: 310907 Patología
Keywords: Haemonchus contortus
Mucosal immunity
Issue Date: 2018
Publisher: 0141-9838
Journal: Parasite Immunology 
Abstract: The experimental protocol of immunization tested here confirms its protective effect against Haemonchus contortus in goats. This protection translated into a 65.5% mean reduction in adult worm burden after a homologous challenge, and a significant decrease (73.2%) in cumulative faecal egg counts (FECs). These parasitological findings were consistent with the levels of some biopathological parameters. Thus, the reduction in adult worms and FEC observed in immunized animals were associated with increased levels of packed cell volume as well as plasma proteins. This response seems to be related to an important increase in specific antibodies (in serum and gastric mucus) and eosinophilia in response to challenge. At the local level, a cellular response was also observed in which CD4(+) lymphocytes and globule leucocytes played a predominant role. Finally, it should be noted that the study of immunolocalization of proteins used in the vaccination trial suggests that these antigens have an internal location (at intestinal and reproductive tissues) in the adult worm. This observation, in conjunction with the kinetics of specific antibody levels after the challenge, suggests that these antigens may be part of excretory/secretory (E/S) products.
ISSN: 0141-9838
DOI: 10.1111/pim.12569
Source: Parasite Immunology [ISSN 0141-9838], v. 40 (9), (Septiembre 2018)
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