P122-F. Micronutrient intake adequacy and mortality risk in the PREDIMED study

Abstract

Background: Limited prospective studies have examined the association between micronutrient intake adequacy and mortality in general population, previous studies have evaluated such associations taking into consideration participants with specific pathologies or critical conditions. We aimed to prospectively assess the association between micronutrient intake adequacy and all-cause, cardiovascular and cancer-related mortality.

Material and methods: The PREDIMED trial is a randomized, controlled trial conducted in Spain from 2003 to 2011 with 7447 participants at high risk for CVD, aged 55 to 80 years. In a post hoc analysis, we assessed the micronutrient intake adequacy for vitamins B1, B2, B6, B12, C, D, E, folic acid, potassium, iron, magnesium, phosphorus and calcium at baseline. Inadequate intake for each nutrient was defined when the intake of the nutrient was below the estimated average requirements (EAR) if available or below the 50% of the adequate intake level for potassium (EAR was not available). We compared participants with inadequate intake for 2, 3 and ≥4 nutrients vs those with one nutrient or none. Main outcomes were all-cause, cancer and cardiovascular mortality and multivariable-adjusted Cox regression models were fitted to estimate hazard ratios (HR, 95% CI).

Results: A total of 402 deaths were recorded after a median follow-up of 4·8 years. Multivariable-adjusted models revealed no statistically significant difference between micronutrient inadequate intakes and all-cause mortality (≥4 micronutrients inadequacy vs 0–1 micronutrients inadequacy ref HR 1·44; 95% CI 0·99–2·11) neither for cancer and cardiovascular mortality.

Conclusions: No statistically significant association was found between micronutrient intake adequacy and all-cause, cancer, and cardiovascular mortality in elderly subjects at high cardiovascular risk.