Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/134975
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dc.contributor.authorMarrero Arencibia, María Isabelen_US
dc.contributor.authorDéniz Cáceres,Antonioen_US
dc.date.accessioned2024-12-11T15:00:13Z-
dc.date.available2024-12-11T15:00:13Z-
dc.date.issued2003en_US
dc.identifier.issn0014-2956en_US
dc.identifier.urihttp://hdl.handle.net/10553/134975-
dc.description.abstractSexual dimorphisms are encountered at every level, i.e. at the behavioral,anatomic, physiological, biochemical, and molecular. Although many of theimprinting and activational events determining anatomic and behavioral sexualdimorphisms have been defined, the factors that regulate gender differencesexpressed at the molecular level are poorly understood. Rat liver is known to beregulated by the gender-dependent profiles of circulating growth hormone (GH).Male rats secrete GH in episodic burst every 3.5–4 h. Between the peaks, GHlevels are undetectable. In female rats, the hormone pulses are more frequent andirregular and are of lower magnitude than those in males, whereas the interpulseconcentrations of GH are always measurable. Single rat hepatocytes microin-jected with the photoprotein aequorin generate oscillations in the cytosolic freeCa 2+ concentration ([Ca 2+]i) when stimulated with agonists acting through thephosphoinositide signaling pathway. In single male rat hepatocytes phenyleph-rine (Phe) and bovine-GH (bGH) induce [Ca2+ ]i oscillations. We investigatedthe effects of Phe and bGH in single female rat hepatocytes microinjected withaequorin. Both agonists are able to induce [Ca 2+ ]i oscillations in single femalehepatocytes similar to those induced in male hepatocytes. The effect of Phe wasthe previously observed with the same concentration range. However, thethreshold concentration for bGH-induced [Ca 2+]i oscillations is a 10-fold lowerthan in male. This difference in the GH-response could play a role in the sexuallydimorphic expression of hepatic enzymes, such as P450 isoforms, regulated bythe gender-dependent secretory GH profiles.en_US
dc.languageengen_US
dc.relation.ispartofEuropean journal of biochemistry (Print)en_US
dc.sourceEuropean journal of biochemistry [ISSN 0014-2956], v. 270 (S1): PS01-0167, p. 65 (Junio 2003)en_US
dc.subject32 Ciencias médicasen_US
dc.subject230215 Hormonasen_US
dc.titleGender differences in the responsiveness of hepatic calcium oscillator to growth hormoneen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.typeConferenceObjecten_US
dc.description.lastpage65en_US
dc.description.firstpage65en_US
dc.relation.volume270en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Póster de congresosen_US
dc.description.numberofpages1en_US
dc.utils.revisionen_US
dc.date.coverdateJunio 2003en_US
dc.identifier.supplement1-
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.contributor.buulpgcBU-MEDen_US
dc.contributor.buulpgcBU-MEDen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr3,001
dc.description.jcrqQ2
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-3732-9929-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMarrero Arencibia, María Isabel-
crisitem.author.fullNameDéniz Cáceres,Antonio-
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