Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/124494
Title: Intracytoplasmic eosinophilic globules in hepatocytes of stranded cetaceans in the Canary islands
Authors: Alves Godinho,Ana 
Monti, G.
Arbelo Hernández, Manuel Antonio 
Silvosa, M.
Sierra Pulpillo, Eva María 
Castro, P.
Jáber Mohamad, José Raduán 
Rodriguez, Francisco 
Fernández Rodríguez, Antonio Jesús 
UNESCO Clasification: 310907 Patología
Issue Date: 2005
Conference: 16th Biennial Conference on the Biology of Marine Mammals (SMM 2005) 
Abstract: The presence in hepatocytes of intracytoplasmic inclusions has been described both in human and in veterinary medicine, being associated to different agents and pathogenic mechanisms. In cetaceans, the presence of this type of globules has been frequently described in animals stranded individual or massively. For the accomplishment of this work, samples of liver, corresponding to 108 cetaceans of 17 different species, stranded in the Canary Islands had been studied. In the cytoplasm of hepatocytes of 58 animals of 12 species, hyalines eosinophilic globules were observed, with a size between 4 and 20 mm. In 49 out of the 58 livers showing those inclusions, histochemical (Pas-diastase) and immunocytochemical (detection of alpha-1- antitrypsine) techniques were perfomed on formaline-fixed, paraffinembedded sections. The results showed 26 positive livers to both techniques, 22 of which were associated with hepatic congestion, 10 were just PAS diastase positive, 6 only a-1-AT positive and 7 negative to both staining procedures. In the present study, the acute hepatic congestion was observed in 53% of the a-1-AT positive animals. The origin of these intracellular changes is probably related to hemodynamic phenomena suffered by the cetaceans stranded alive, in addition to hyperthermia and/or other factors wich may induce the production and storage of a-1-AT and as other acute phase proteins (under current study) in the hepatocytes.
URI: http://hdl.handle.net/10553/124494
Source: 16th Biennial Conference on the Biology of Marine Mammals (SMM 2005)
Appears in Collections:Póster de congreso
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