Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/76581
Title: Anti-inflammatory drugs suppress injury-induced NADPH-d activity in CA1 pyramidal neurones
Authors: Regidor García, José 
Montesdeoca, José 
Ramírez González, Juan Andrés 
Sosa Pérez, Carmen Dolores 
Hernández-Urquía, Concepción M.
Feria, Manuel
Divac, Ivan
UNESCO Clasification: 320990 Farmacología experimental
320507 Neurología
Keywords: Long-Term Potentiation
Dexamethasone
Indomethacin
L-Name
Issue Date: 1994
Journal: NeuroReport 
Abstract: Inducibility of NADPH-diaphorase (NADPH-d) or nitric oxide synthase (NOS) has been demonstrated in pyramidal neurones of the hippocampus, but the mechanisms of this induction are not known. The present study aimed to assess the role of anti-inflammatory drugs in injury-induced production of NADPH-d/NOS in CA1 pyramidal neurones. We found that either a steroid, dexamethasone or a non-steroid, indomethacin, prevents induction of these enzymes. We also found that NO is not necessary for the induction. None of the three drugs used had detectable effect on the neurones which contain constitutive NADPH-d/NOS.
URI: http://hdl.handle.net/10553/76581
ISSN: 0959-4965
DOI: 10.1097/00001756-199409080-00020
Source: Neuroreport [ISSN 0959-4965], v. 5 (14), p. 1766-1768, (Septiembre 1994)
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