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Title: Manganese-Catalyzed Regioselective Dehydrogenative C- versus N-Alkylation Enabled by a Solvent Switch: Experiment and Computation
Authors: Borghs, Jannik C.
Zubar, Viktoriia
Azofra Mesa, Luis Miguel 
Sklyaruk, Jan
Rueping, Magnus
UNESCO Clasification: 221001 Catálisis
Issue Date: 2020
Journal: Organic Letters 
Abstract: The first base metal-catalyzed regioselective dehydrogenative alkylation of indolines using readily available alcohols as the alkylating reagent is reported. A single air- and moisture-stable manganese catalyst provides access to either C3- or N-alkylated indoles depending on the solvent used. Mechanistic studies indicate that the reaction takes place through a combined acceptorless dehydrogenation and hydrogen autotransfer strategy.
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.0c01270
Source: Organic Letters [ISSN 1523-7060], v. 22 (11), p. 4222–4227 (Enero 2020)
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