Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69847
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dc.contributor.authorDiaz Delgado, Josueen_US
dc.contributor.authorGroch, Kátia R.en_US
dc.contributor.authorSierra Pulpillo, Eva Maríaen_US
dc.contributor.authorSacchini, Simonaen_US
dc.contributor.authorSucca, Danieleen_US
dc.contributor.authorQuesada Canales, Ildefonso Óscaren_US
dc.contributor.authorArbelo Hernández, Manuel Antonioen_US
dc.contributor.authorFernández Rodríguez, Antonio Jesúsen_US
dc.contributor.authorSantos, Elitierien_US
dc.contributor.authorIkeda, Joanaen_US
dc.contributor.authorCarvalho, Rafaelen_US
dc.contributor.authorAzevedo, Alexandre F.en_US
dc.contributor.authorLailson-Brito, Joseen_US
dc.contributor.authorFlach, Leonardoen_US
dc.contributor.authorRessio, Rodrigoen_US
dc.contributor.authorKanamura, Cristina T.en_US
dc.contributor.authorSansone, Marceloen_US
dc.contributor.authorFavero, Cíntiaen_US
dc.contributor.authorPorter, Brian F.en_US
dc.contributor.authorCentelleghe, Cinziaen_US
dc.contributor.authorMazzariol, Sandroen_US
dc.contributor.authorRenzo, Ludovica Dien_US
dc.contributor.authorFrancesco, Gabriella Dien_US
dc.contributor.authorGuardo, Giovanni Dien_US
dc.contributor.authorCatão-Dias, José Luizen_US
dc.date.accessioned2020-02-05T12:50:43Z-
dc.date.available2020-02-05T12:50:43Z-
dc.date.issued2019en_US
dc.identifier.issn1932-6203en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/69847-
dc.description.abstractThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Cetacean morbillivirus (CeMV) is a major natural cause of morbidity and mortality in cetaceans worldwide and results in epidemic and endemic fatalities. The pathogenesis of CeMV has not been fully elucidated, and questions remain regarding tissue tropism and the mechanisms of immunosuppression. We compared the histopathologic and viral immunohistochemical features in molecularly confirmed CeMV-infected Guiana dolphins (Sotalia guianensis) from the Southwestern Atlantic (Brazil) and striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from the Northeast-Central Atlantic (Canary Islands, Spain) and the Western Mediterranean Sea (Italy). Major emphasis was placed on the central nervous system (CNS), including neuroanatomical distribution of lesions, and the lymphoid system and lung were also examined. Eleven Guiana dolphins, 13 striped dolphins, and 3 bottlenose dolphins were selected by defined criteria. CeMV infections showed a remarkable neurotropism in striped dolphins and bottlenose dolphins, while this was a rare feature in CeMV-infected Guiana dolphins. Neuroanatomical distribution of lesions in dolphins stranded in the Canary Islands revealed a consistent involvement of the cerebrum, thalamus, and cerebellum, followed by caudal brainstem and spinal cord. In most cases, Guiana dolphins had more severe lung lesions. The lymphoid system was involved in all three species, with consistent lymphoid depletion. Multinucleate giant cells/ syncytia and characteristic viral inclusion bodies were variably observed in these organs. Overall, there was widespread lymphohistiocytic, epithelial, and neuronal/neuroglial viral antigen immunolabeling with some individual, host species, and CeMV strain differences. Preexisting and opportunistic infections were common, particularly endoparasitism, followed by bacterial, fungal, and viral infections. These results contribute to understanding CeMV infections in susceptible cetacean hosts in relation to factors such as CeMV strains and geographic locations, thereby establishing the basis for future neuro- and immunopathological comparative investigations.en_US
dc.languageengen_US
dc.relation.ispartofPLoS ONEen_US
dc.sourcePLoS ONE [ISSN 1932-6203], v. 14 (3), e0213363.en_US
dc.subject310907 Patologíaen_US
dc.subject3105 Peces y fauna silvestreen_US
dc.subject.otherDolphinsen_US
dc.subject.otherCerebrumen_US
dc.subject.otherCentral nervous systemen_US
dc.subject.otherLymph nodesen_US
dc.subject.otherSpleenen_US
dc.subject.otherNeuronsen_US
dc.subject.otherRespiratory infectionsen_US
dc.subject.otherOpportunistic infectionsen_US
dc.titleComparative histopathologic and viral immunohistochemical studies on CeMV infection among Western Mediterranean, Northeast-Central, and Southwestern Atlantic cetaceansen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0213363en_US
dc.identifier.scopus85063277099-
dc.identifier.isi000461765900039-
dc.contributor.authorscopusid54787562800-
dc.contributor.authorscopusid37072358500-
dc.contributor.authorscopusid15742962600-
dc.contributor.authorscopusid55185147800-
dc.contributor.authorscopusid56006896100-
dc.contributor.authorscopusid55429764500-
dc.contributor.authorscopusid6603561403-
dc.contributor.authorscopusid57212084410-
dc.contributor.authorscopusid57207934019-
dc.contributor.authorscopusid57203099617-
dc.contributor.authorscopusid56144762100-
dc.contributor.authorscopusid8278386900-
dc.contributor.authorscopusid8899587100-
dc.contributor.authorscopusid24474200300-
dc.contributor.authorscopusid35732104100-
dc.contributor.authorscopusid6603160626-
dc.contributor.authorscopusid57200079610-
dc.contributor.authorscopusid55313218300-
dc.contributor.authorscopusid7201565300-
dc.contributor.authorscopusid55573906900-
dc.contributor.authorscopusid24173815500-
dc.contributor.authorscopusid57207928540-
dc.contributor.authorscopusid57207925980-
dc.contributor.authorscopusid26664524800-
dc.contributor.authorscopusid6602455809-
dc.identifier.issue3-
dc.relation.volume14en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
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dc.description.numberofpages21en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Diaz-Delgado, J-
dc.contributor.wosstandardWOS:Groch, KR-
dc.contributor.wosstandardWOS:Sierra, E-
dc.contributor.wosstandardWOS:Sacchini, S-
dc.contributor.wosstandardWOS:Zucca, D-
dc.contributor.wosstandardWOS:Quesada-Canales, O-
dc.contributor.wosstandardWOS:Arbelo, M-
dc.contributor.wosstandardWOS:Fernandez, A-
dc.contributor.wosstandardWOS:Santos, E-
dc.contributor.wosstandardWOS:Ikeda, J-
dc.contributor.wosstandardWOS:Carvalho, R-
dc.contributor.wosstandardWOS:Azevedo, AF-
dc.contributor.wosstandardWOS:Lailson-Brito, J-
dc.contributor.wosstandardWOS:Flach, L-
dc.contributor.wosstandardWOS:Ressio, R-
dc.contributor.wosstandardWOS:Kanamura, CT-
dc.contributor.wosstandardWOS:Sansone, M-
dc.contributor.wosstandardWOS:Favero, C-
dc.contributor.wosstandardWOS:Porter, BF-
dc.contributor.wosstandardWOS:Centelleghe, C-
dc.contributor.wosstandardWOS:Mazzariol, S-
dc.contributor.wosstandardWOS:Di Renzo, L-
dc.contributor.wosstandardWOS:Di Francesco, G-
dc.contributor.wosstandardWOS:Di Guardo, G-
dc.contributor.wosstandardWOS:Catao-Dias, JL-
dc.date.coverdateMarzo 2019en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,1
dc.description.jcr2,776
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
dc.description.erihplusERIH PLUS
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR Histología y Patología Veterinaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR Histología y Patología Veterinaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0003-1216-5446-
crisitem.author.orcid0000-0003-3749-8845-
crisitem.author.orcid0000-0001-6493-1275-
crisitem.author.orcid0000-0002-1623-5010-
crisitem.author.orcid0000-0001-5281-0521-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameDiaz Delgado, Josue-
crisitem.author.fullNameSierra Pulpillo, Eva María-
crisitem.author.fullNameSacchini, Simona-
crisitem.author.fullNameSucca, Daniele-
crisitem.author.fullNameQuesada Canales, Ildefonso Óscar-
crisitem.author.fullNameArbelo Hernández, Manuel Antonio-
crisitem.author.fullNameFernández Rodríguez, Antonio Jesús-
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