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Title: Recent Advances on Cytotoxic Sesquiterpene Lactones
Authors: Quintana, José 
Estévez, Francisco 
UNESCO Clasification: 2302 Bioquímica
2407 Biología celular
Keywords: Sesquiterpene lactones
Cell death, et al
Issue Date: 2018
Journal: Current Pharmaceutical Design 
Abstract: Sesquiterpene lactones are naturally occurring compounds that have attracted considerable attention because to their vast array of biological activities. These plant-derived compounds contain the α-methylene-γ- butyrolactone functional group, which is the structural requirement for their pharmacological activities. Many of them exhibit cancer cell cytotoxicity and are promising anticancer agents through multiple mechanisms of action. Sesquiterpene lactones are alkylating agents that form covalent adducts in vivo and inhibit enzymes and key proteins. They are also potent apoptotic inducers in several cancer cells. This kind of cell death is recognized as a property that is useful for identifying anticancer drugs. This review focuses on the advances on cytotoxic sesquiterpene lactones and specifically the signal transduction pathways of cell death triggered in cancer cells.
ISSN: 1381-6128
DOI: 10.2174/1381612825666190119114323
Source: Current Pharmaceutical Design [ISSN 1381-6128], v. 24 (36), p. 4355 - 4361
Appears in Collections:Reseña
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