Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/54395
Título: Schistosoma mansoni: A diagnostic approach to detect acute schistosomiasis infection in a murine model by PCR
Autores/as: Sandoval, Nidia
Siles-Lucas, Mar
Aban, Julio Lopez
Pérez-Arellano, José Luis 
Gárate, Teresa
Muro, Antonio
Palabras clave: Polymerase-Chain-Reaction
Antigen
Urine
Dna
Fecha de publicación: 2006
Editor/a: 0014-4894
Publicación seriada: Experimental parasitology 
Resumen: Schistosomiasis represents an increasing problem in non-endemic areas, due to the growing number of immigrants and to tourists contracting this disease in "off-the-beaten-track" tourism. Acute schistosomiasis is not diagnosed early due to the lack of diagnostic tools that are sufficiently sensitive enough to detect the parasite during the first weeks of infection. We have developed a diagnostic approach based on the detection of parasite DNA by polymerase chain reaction (PCR) in urine, comparing the performance of this new approach with the two currently used schistosomiasis diagnostic tools (Kato-Katz and ELISA) and the PCR in stool samples. This comparison was done in a Schistosoma mansoni murine experimental model, which permits follow up of the parasite from the acute to the chronic stage of infection. Our results suggest that this new PCR-based approach could be useful for the detection of acute schistosomiasis in easy-to-handle clinical samples such the urine. (c) 2006 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10553/54395
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2006.02.012
Fuente: Experimental Parasitology[ISSN 0014-4894],v. 114, p. 84-88
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