Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54294
DC FieldValueLanguage
dc.contributor.authorEspinoza, Elsa Y.en_US
dc.contributor.authorPérez-Arellano, José L.en_US
dc.contributor.authorCarranza Rodríguez, Cristinaen_US
dc.contributor.authorCollía, Franciscoen_US
dc.contributor.authorMuro, Antonioen_US
dc.date.accessioned2019-02-18T09:52:29Z-
dc.date.available2019-02-18T09:52:29Z-
dc.date.issued2002en_US
dc.identifier.issn0141-9838en_US
dc.identifier.urihttp://hdl.handle.net/10553/54294-
dc.description.abstractThe direct effect of nitric oxide (NO) on the viability of Toxocara canis larvae was studied. We observed that the nitric oxide donors, SIN-1 and SNOG, exert no cytotoxic effect on the in vitro viability of T. canis larvae. In addition, we developed a model in rats to elucidate the role of NO during T. canis infection. We evaluated different indicators in four experimental groups: morphological parameters, the total number cells and cell types recovered, nitrite and protein concentration, lactate dehydrogenase and alkaline phosphatase enzymatic activity in the bronchoalveolar lavage fluid, lung index and detection of anti- T. canis specific antibodies. We observed significant differences between non-infected and infected groups. The infected animals treated with the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine were less damaged than infected, non-treated animals. Our results suggest that the in vivo inhibition of the synthesis of NO triggered by iNOS diminishes the deleterious effects of the parasite upon the host, especially the vascular alterations in the lungs. We could show that in vivo production of NO induced by infection with T. canis results in direct host damage. Thus, this induction may constitute an evasion/adaptation mechanism of the parasite.en_US
dc.languageengen_US
dc.relation.ispartofParasite Immunologyen_US
dc.sourceParasite Immunology [ISSN 0141-9838], v. 24, p. 511-520 (Noviembre 2002)en_US
dc.subject32 Ciencias médicasen_US
dc.subject310903 Inmunologíaen_US
dc.subject.otherHypersensitivity Pneumonitisen_US
dc.subject.otherBrugia-Malayien_US
dc.subject.otherActivated Macrophagesen_US
dc.subject.otherAlveolar Macrophagesen_US
dc.subject.otherSchistosoma-Mansonien_US
dc.subject.otherLavage Fluiden_US
dc.subject.otherHost-Defenseen_US
dc.subject.otherMouseen_US
dc.subject.otherMiceen_US
dc.subject.otherAminoguanidineen_US
dc.titleIn vivo inhibition of inducible nitric oxide synthase decreases lung injury induced by Toxocara canis in experimentally infected ratsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1046/j.1365-3024.2002.00598.xen_US
dc.identifier.scopus0038030657-
dc.identifier.isi000182261900002-
dc.contributor.authorscopusid7004660805-
dc.contributor.authorscopusid7005553929-
dc.contributor.authorscopusid6603949899-
dc.contributor.authorscopusid6602234846-
dc.contributor.authorscopusid7006690116-
dc.description.lastpage520en_US
dc.description.firstpage511en_US
dc.relation.volume24en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid5314492-
dc.contributor.daisngid445671-
dc.contributor.daisngid344572-
dc.contributor.daisngid1575238-
dc.contributor.daisngid409562-
dc.description.numberofpages10en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Espinoza, EY-
dc.contributor.wosstandardWOS:Perez-Arellano, JL-
dc.contributor.wosstandardWOS:Carranza, C-
dc.contributor.wosstandardWOS:Collia, F-
dc.contributor.wosstandardWOS:Muro, A-
dc.date.coverdateNoviembre 2002en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,633-
dc.description.jcrqQ3-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Didácticas Específicas-
crisitem.author.orcid0000-0002-2936-8242-
crisitem.author.orcid0000-0002-2768-0072-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePérez Arellano, José Luis-
crisitem.author.fullNameCarranza Rodríguez, Cristina-
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