Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/52998
Título: Replication of relevant SNPs associated with cardiovascular disease susceptibility obtained from GWAs in a case-control study in a Canarian population
Autores/as: Rodriguez Esparragon, Francisco 
Companioni, Osmel
Garcia Bello, Miguel
Buset Rios, Nisa
Rodriguez Perez, Jose Carlos 
Palabras clave: Coronary-Artery-Disease
Single-Nucleotide Polymorphisms
Myocardial-Infarction
Gene Polymorphisms
Chromosome 9P21.3, et al.
Fecha de publicación: 2012
Editor/a: 0278-0240
Publicación seriada: Disease Markers 
Resumen: Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). We tested for replication of the previously described association with CAD in our case-control datasets of SNPs variants located at 1p13.1, 2q33.1, 10q11.1, 9p21, and 21q22. We observed a small significant risk associated of the SNP rs10757274 with CAD in the PROCAGENE study. Besides, the multilocus combination rs10757274 and rs1333048 gave a near significant result. We confirmed that the SNP rs10757274 showed association with CAD in the PROCAGENE study, although after applying the Bonferroni correction was not longer significant. Independent replication studies in other populations are needed to unequivocally confirm the association.
URI: http://hdl.handle.net/10553/52998
ISSN: 0278-0240
DOI: 10.3233/DMA-2011-0879
Fuente: Disease Markers[ISSN 0278-0240],v. 32 (4), p. 231-239
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