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Title: Replication of relevant SNPs associated with cardiovascular disease susceptibility obtained from GWAs in a case-control study in a Canarian population
Authors: Rodriguez Esparragon, Francisco 
Companioni, Osmel
Garcia Bello, Miguel
Buset Rios, Nisa
Rodriguez Perez, Jose Carlos 
Keywords: Coronary-Artery-Disease
Single-Nucleotide Polymorphisms
Gene Polymorphisms
Chromosome 9P21.3, et al
Issue Date: 2012
Publisher: 0278-0240
Journal: Disease Markers 
Abstract: Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). We tested for replication of the previously described association with CAD in our case-control datasets of SNPs variants located at 1p13.1, 2q33.1, 10q11.1, 9p21, and 21q22. We observed a small significant risk associated of the SNP rs10757274 with CAD in the PROCAGENE study. Besides, the multilocus combination rs10757274 and rs1333048 gave a near significant result. We confirmed that the SNP rs10757274 showed association with CAD in the PROCAGENE study, although after applying the Bonferroni correction was not longer significant. Independent replication studies in other populations are needed to unequivocally confirm the association.
ISSN: 0278-0240
DOI: 10.3233/DMA-2011-0879
Source: Disease Markers[ISSN 0278-0240],v. 32 (4), p. 231-239
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