Please use this identifier to cite or link to this item:
Title: Ent-Labdane diterpenoids from the aerial parts of eupatorium obtusissmum
Authors: Castillo, Q.A.
Triana, Jorge
Eiroa, José Luis 
Calcul, L.
Rivera, E.
Wojtas, L.
Padrón, J.M.
Boberieth, L.
Keramane, M.
Abel-Santos, E.
Báez, L.A.
Germosén, E.A.
UNESCO Clasification: 2302 Bioquímica
Keywords: Absolute-Configuration
Issue Date: 2016
Journal: Journal of Natural Products 
Abstract: Six new ent-labdane diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 μM.
ISSN: 0163-3864
DOI: 10.1021/acs.jnatprod.5b00954
Source: Journal of Natural Products [ISSN 0163-3864], v. 79 (4), p. 907-913
Appears in Collections:Artículos
Show full item record

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.