Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50578
Title: Steroidal saponins from the bark of Dracaena draco and their cytotoxic activities
Authors: González, Antonio G. 
Hernández, Juan C.
León, Francisco
Padrón, Juan I.
Estévez, Francisco 
Quintana, J 
Bermejo, Jaime
Keywords: Dragons Blood
Hl-60 Cells
Leukemia
Growth
Assay
Issue Date: 2003
Publisher: 0163-3864
Journal: Journal of Natural Products 
Abstract: From the stem bark of Dracaena draco, three new compounds, namely, draconins A-C (1-3), were isolated, along with 17 known compounds. The structures of the new compounds isolated were elucidated on the basis of spectroscopic data interpretation. Several of the isolated compounds showed potent cytotoxic activities measured on the human leukemia cell line HL-60 (IC50's from 2.0 to 9.7 muM at 72 h). The mechanism by which compounds 1 and 2 display their cytostatic properties is through induction of cell death by apoptosis, as evaluated by fluorescence microscopy and DNA fragmentation.
URI: http://hdl.handle.net/10553/50578
ISSN: 0163-3864
DOI: 10.1021/np020517j
Source: Journal of Natural Products[ISSN 0163-3864],v. 66, p. 793-798
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