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Title: Isolation from Eucalyptus occidentalis and Identification of a New Kaempferol Derivative that Induces Apoptosis in Human Myeloid Leukemia Cells
Authors: Benyahia, Samira
Benayache, Samir
Benayache, Fadila
Quintana, J 
López, Matías
León, Francisco
Hernández, Juan C.
Estevez, F 
Bermejo, Jaime
Keywords: Flavonoids
Issue Date: 2004
Publisher: 0163-3864
Journal: Journal of Natural Products 
Abstract: In this paper we report the isolation and structural elucidation of a new flavonoid (1) and three known compounds, 6,8-di-C-methylkaempferol 3-methyl ether (2), oleanolic acid, and 2alpha,3beta-dihydroxyurs-12-en-28-oic acid, from aerial parts of Eucalyptus occidentalis collected in Algeria. Flavonoids 1 and 2 were used to study their biological activities on the human promyelocytic leukemia cell line, HL-60. Our data show that these compounds induce morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death, which is mediated by caspase-8/caspase-3 activation and cytochrome c release.
ISSN: 0163-3864
DOI: 10.1021/np049960f
Source: Journal Of Natural Products[ISSN 0163-3864],v. 67 (4), p. 527-531
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