|Title:||Isolation from Eucalyptus occidentalis and Identification of a New Kaempferol Derivative that Induces Apoptosis in Human Myeloid Leukemia Cells||Authors:||Benyahia, Samira
Hernández, Juan C.
|Issue Date:||2004||Publisher:||0163-3864||Journal:||Journal of Natural Products||Abstract:||In this paper we report the isolation and structural elucidation of a new flavonoid (1) and three known compounds, 6,8-di-C-methylkaempferol 3-methyl ether (2), oleanolic acid, and 2alpha,3beta-dihydroxyurs-12-en-28-oic acid, from aerial parts of Eucalyptus occidentalis collected in Algeria. Flavonoids 1 and 2 were used to study their biological activities on the human promyelocytic leukemia cell line, HL-60. Our data show that these compounds induce morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death, which is mediated by caspase-8/caspase-3 activation and cytochrome c release.||URI:||http://hdl.handle.net/10553/50575||ISSN:||0163-3864||DOI:||10.1021/np049960f||Source:||Journal Of Natural Products[ISSN 0163-3864],v. 67 (4), p. 527-531|
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