Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50572
Title: Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells
Authors: Léon, Francisco
Quintana, J 
Rivera, Augusto
Estevez, F 
Bermejo, Jaime
Keywords: Fungi
Acid
Identification
Constituents
Activation, et al
Issue Date: 2004
Publisher: 0163-3864
Journal: Journal of Natural Products 
Abstract: A new lanostanoid triterpene, 3-oxosulfurenic acid (1), together with three known triterpenes (3, 4, and 7) were isolated from the fruit bodies of Laetiporus sulphureus. Cytotoxicity of these compounds and their derivatives (2, 5, and 6) was evaluated on HL-60 cells. Further studies revealed that acetyl eburicoic acid (5) was the most potent apoptosis inducer. Apoptosis was accompanied by both the activation of caspase-3 and the fragmentation of poly(ADP-ribose) polymerase-1 and was also associated with an early release of cytochrome c from the mitochondria.
URI: http://hdl.handle.net/10553/50572
ISSN: 0163-3864
DOI: 10.1021/np049762o
Source: Journal Of Natural Products[ISSN 0163-3864],v. 67 (12), p. 2008-2011
Appears in Collections:Artículos
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