Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/50572
Título: | Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells | Autores/as: | Léon, Francisco Quintana, J Rivera, Augusto Estevez, F Bermejo, Jaime |
Clasificación UNESCO: | 32 Ciencias médicas | Palabras clave: | Fungi Acid Identification Constituents Activation, et al. |
Fecha de publicación: | 2004 | Publicación seriada: | Journal of Natural Products | Resumen: | A new lanostanoid triterpene, 3-oxosulfurenic acid (1), together with three known triterpenes (3, 4, and 7) were isolated from the fruit bodies of Laetiporus sulphureus. Cytotoxicity of these compounds and their derivatives (2, 5, and 6) was evaluated on HL-60 cells. Further studies revealed that acetyl eburicoic acid (5) was the most potent apoptosis inducer. Apoptosis was accompanied by both the activation of caspase-3 and the fragmentation of poly(ADP-ribose) polymerase-1 and was also associated with an early release of cytochrome c from the mitochondria. | URI: | http://hdl.handle.net/10553/50572 | ISSN: | 0163-3864 | DOI: | 10.1021/np049762o | Fuente: | Journal Of Natural Products[ISSN 0163-3864],v. 67 (12), p. 2008-2011 |
Colección: | Artículos |
Citas SCOPUSTM
56
actualizado el 22-dic-2024
Citas de WEB OF SCIENCETM
Citations
44
actualizado el 22-dic-2024
Visitas
48
actualizado el 29-jun-2024
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.