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Title: A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells
Authors: León, Francisco
Brouard Martín,Ignacio 
Torres, Fernando
Quintana, Jose 
Rivera, Augusto
Estevez, Francisco 
Bermejo, Jaime
UNESCO Clasification: 32 Ciencias médicas
320713 Oncología
3209 Farmacología
Keywords: Fungi
Issue Date: 2008
Journal: Chemistry and Biodiversity 
Abstract: A new phytosphingosine-type ceramide, suillumide (1), was isolated from the EtOH extract of the basidiomycete Suillus luteus (L.) S. E GRAY, along with ten known compounds: ergosta-4,6,8(14),22-tetraen-3-one, ergosterol, ergosterol peroxide, suillin, (E)-3,4,5-trimethoxycinnamic alcohol, 5 alpha,6 alpha-epoxyergosta-8,22-diene-3 beta,7 beta-diol, (R)-1-palmitoylglycerol, ergosta-7,9(11),22-triene-3 beta,5 alpha,6 beta-triol, cerevisterol, and 4-hydroxybenzoic acid. The structure of 1 was determined on the basis of spectroscopic and mass-spectrometric analyses, as well as by chemical methods. Compound 1 and its synthetic diacetyl derivative 2 were tested for their cytotoxic activities against the human melanoma cell line SK-MEL-1. Both drugs showed IC50 values of ca. 10 mu m after 72 h of exposure.
ISSN: 1612-1872
DOI: 10.1002/cbdv.200890002
Source: Chemistry & Biodiversity[ISSN 1612-1872],v. 5 (1), p. 120-125 (Febrero 2008)
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