Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48743
Title: Ultrastructural Changes in the Venous Wall Induced by Experimental Diabetes: Preliminary Findings
Authors: Mompeó, B. 
Ortega, Francisco
Sarmiento, L.
Keywords: Endothelium
Mellitus
Arterial
Hypertension
Collagen, et al
Issue Date: 1995
Publisher: 0268-3555
Journal: Phlebology 
Abstract: Objective: To study whether experimental streptozotocin (STZ) induced diabetes results in structural alterations to the venous wall of the femoral vein in adult rats, in order to develop further studies using this model.Design: A prospective study of femoral veins obtained from controls and STZ-induced diabetes rats.Setting: Department of Morphology, Universidad de Las Palmas de Gran Canaria, Spain.Interventions: Experimental diabetes induced by intraperitoneal injection of streptozotocin.Main outcome measures: The samples were studied at 6 and 12 weeks post-injection using light and transmission electron microscopy.Results: The results show that the venous wall is affected by an increase in the deposition of extracellular tissue. In addition the endothelial, muscular and adventitial cells show morphological changes.Conclusions: Our results demonstrate significant alterations in the venous wall due to hyperglycaemia in the STZ-animal model.
URI: http://hdl.handle.net/10553/48743
ISSN: 0268-3555
DOI: 10.1177/026835559501000208
Source: Phlebology[ISSN 0268-3555],v. 10 (2), p. 69-74
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