Please use this identifier to cite or link to this item:
Title: Isolation of (s)-(+)-naproxene from Musa acuminata. Inhibitory effect of naproxene and its 7-methoxy isomer on constitutive COX-1 and inducible COX-2
Authors: Abad, T.
McNaughton-Smith, G.
Fletcher, W. Q.
Echeverri, F.
Diaz-Peñate, R.
Tabraue, C 
Ruiz De Galarreta, C. M.
López-Blanco, F. 
Luis, J. G.
UNESCO Clasification: 32 Ciencias médicas
3209 Farmacología
Keywords: Phenalenone-Type Phytoalexins
Issue Date: 2000
Journal: Planta Medica 
Abstract: The isolation and characterisation of (S)-(+)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, a well known synthetic non-steroidal anti-inflammatory drug (naproxene), from a natural source is described for the first time. We evaluated the ability of naproxene and its 7-methoxy isomer to abrogate constitutive COX-1 and inducible COX-2 activity in human A549 cells. Naproxene inhibited COX-1 (IC50 = 3.42 mu M) and COX-2 (IC50 = 1.53 mu M), whereas the 7-methoxy isomer had no appreciable effect on COX-1 (IC50 much greater than 100 mu M) but also abrogated the activity of COX-2 enzyme (IC50 = 14.42 mu M).
ISSN: 0032-0943
DOI: 10.1055/s-2000-8581
Source: Planta Medica[ISSN 0032-0943],v. 66 (5), p. 471-473
Appears in Collections:Artículos
Show full item record

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.