Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/48246
Title: Indium catalyzed solvent-free multicomponent synthesis of cytotoxic dibenzo[a,h]anthracenes from aldehydes, 2-hydroxy-1,4-naphthoquinone, and 2-naphthol
Authors: Hueso-Falcón, Idaira
Amesty, Ángel
Martin, Patricia 
López-Rodríguez, Matías
Fernández-Pérez, Leandro 
Estévez-Braun, Ana
Keywords: One-Pot Syntheses
Privileged Structures
Quinone Methides
Efficient
Derivatives, et al
Issue Date: 2014
Publisher: 0040-4020
Project: "Evaluación Preclinica de Nuevas Estructuras Quimicas Diseñadas Para Inhibir la Ruta Oncogenica Jak-Stat O Como Moduladores Selectivos de Los Receptores Estrógenos" 
Journal: Tetrahedron 
Abstract: A series of dibenzo[a,h]anthracene derivatives were synthesized through a straightforward, one-pot protocol based on a three-component reaction with 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes, and 2-naphthol as synthetic inputs, using InCl3 a catalyst under solvent-free conditions. Most of the obtained ortho-quinonic adducts were cytotoxic against HEL and MCF-7 tumoral cell lines. (C) 2014 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/48246
ISSN: 0040-4020
DOI: 10.1016/j.tet.2014.09.076
Source: Tetrahedron[ISSN 0040-4020],v. 70, p. 8480-8487
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