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Title: | Indium catalyzed solvent-free multicomponent synthesis of cytotoxic dibenzo[a,h]anthracenes from aldehydes, 2-hydroxy-1,4-naphthoquinone, and 2-naphthol | Authors: | Hueso-Falcón, Idaira Amesty, Ángel Martin, Patricia López-Rodríguez, Matías Fernández-Pérez, Leandro Estévez-Braun, Ana |
UNESCO Clasification: | 32 Ciencias médicas 2302 Bioquímica |
Keywords: | One-Pot Syntheses Privileged Structures Quinone Methides Efficient Derivatives, et al |
Issue Date: | 2014 | Project: | "Evaluación Preclinica de Nuevas Estructuras Quimicas Diseñadas Para Inhibir la Ruta Oncogenica Jak-Stat O Como Moduladores Selectivos de Los Receptores Estrógenos" | Journal: | Tetrahedron | Abstract: | A series of dibenzo[a,h]anthracene derivatives were synthesized through a straightforward, one-pot protocol based on a three-component reaction with 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes, and 2-naphthol as synthetic inputs, using InCl3 a catalyst under solvent-free conditions. Most of the obtained ortho-quinonic adducts were cytotoxic against HEL and MCF-7 tumoral cell lines. | URI: | http://hdl.handle.net/10553/48246 | ISSN: | 0040-4020 | DOI: | 10.1016/j.tet.2014.09.076 | Source: | Tetrahedron[ISSN 0040-4020],v. 70, p. 8480-8487 |
Appears in Collections: | Artículos |
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