Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47548
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dc.contributor.authorMozos Mora, Elenaen_US
dc.contributor.authorHerráez Thomas, Pedro Manuelen_US
dc.contributor.authorPérez Arevalo,Joseen_US
dc.contributor.authorFernández Rodríguez, Antonio Jesúsen_US
dc.contributor.authorBlanco Rodríguez, Alfonsoen_US
dc.contributor.authorMartín, M. P.en_US
dc.contributor.authorJover Moyano, Amadoren_US
dc.contributor.otherPerez, Jose-
dc.contributor.otherFernandez, Antonio-
dc.date.accessioned2018-11-23T14:26:14Z-
dc.date.available2018-11-23T14:26:14Z-
dc.date.issued2003en_US
dc.identifier.issn0341-6593en_US
dc.identifier.urihttp://hdl.handle.net/10553/47548-
dc.description.abstractHistopathological, immunohistochemical and ultrastructural cutaneous changes are described in acute and subacute forms of experimental African Swine Fever (ASF). Fourteen 3-month-old Large White cross pigs were infected intramuscularly with the Dominican Republic 78 (DR78) ASF virus isolate and euthanised in pairs on alternatives days (3 to 17) post-inoculation (dpi). Three pigs were found dead at 8, 10 and 13 dpi, respectively. Antibodies against viral antigen Vp73, human fibrinogen, glycoprotein IIIa and Factor VIII-ra were used to evaluate viral antigen distribution, fibrin microthrombi and platelets in dermal vessels, respectively. Cutaneous lesions were characterised by vascular changes ranging from hyperaemia, mild oedema, scarce fibrin microthrombi and microhaemorrhages in euthanised animals, to generalized fibrin microthrombosis and microhaemorrhages in dead pigs. Secondary pustules and superficial folliculitis were observed in two animals dead at 10 and 13 dpi. Diffuse cytoplasmic Vp73 labelling was found in numerous intravascular monocytes and dermal macrophages. Ultrastructural studies showed mature viral particles in the lumen of dermal vessels but viral replication was not observed; nonetheless, microtubuloreticular structures were observed in the cytoplasm of some endothelial cells and macrophages which showed cytopathic effects, signs of cell activation or degeneration. Morphological and immunohistochemical evidences of platelet activation, degranulation and consumption were observed from 5 dpi onward.en_US
dc.languageengen_US
dc.publisher0341-6593
dc.relation.ispartofDeutsche tierarztliche Wochenschriften_US
dc.sourceDeutsche Tierarztliche Wochenschrift [ISSN 0341-6593], v. 110 (4), p. 150-154en_US
dc.subject240111 Patología animalen_US
dc.subject310907 Patologíaen_US
dc.subject.otherExperimental African swine feveren_US
dc.subject.otherImmunohistochemistryen_US
dc.subject.otherPigen_US
dc.subject.otherSkinen_US
dc.subject.otherUltrastructureen_US
dc.titleCutaneous lesions in experimental acute and subacute African swine fever: An immunohistopathological and ultrastructural studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.scopus0042768051-
dc.identifier.isi000183294200005-
dcterms.isPartOfDeutsche Tierarztliche Wochenschrift
dcterms.sourceDeutsche Tierarztliche Wochenschrift[ISSN 0341-6593],v. 110 (4), p. 150-154
dc.contributor.authorscopusid7003461159-
dc.contributor.authorscopusid57194503614-
dc.contributor.authorscopusid55597088286-
dc.contributor.authorscopusid55597088351-
dc.contributor.authorscopusid56673009900-
dc.contributor.authorscopusid16738146000-
dc.contributor.authorscopusid7202801089-
dc.contributor.authorscopusid36917409700-
dc.contributor.authorscopusid57198189938-
dc.description.lastpage154en_US
dc.description.firstpage150en_US
dc.relation.volume110en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000183294200005-
dc.contributor.daisngid676422-
dc.contributor.daisngid523902-
dc.contributor.daisngid319037-
dc.contributor.daisngid176520-
dc.contributor.daisngid410842-
dc.contributor.daisngid4474690-
dc.contributor.daisngid1329280-
dc.identifier.investigatorRIDK-1353-2014-
dc.identifier.investigatorRIDG-3448-2015-
dc.utils.revisionen_US
dc.date.coverdateAbril 2003en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.jcr0,413
dc.description.jcrqQ3
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0001-9316-2882-
crisitem.author.orcid0000-0001-5281-0521-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHerráez Thomas, Pedro Manuel-
crisitem.author.fullNamePérez Arevalo,Jose-
crisitem.author.fullNameFernández Rodríguez, Antonio Jesús-
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