Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47060
Title: Sesquiterpenoid derivatives from Gonospermum elegans and their cytotoxic activity for HL-60 human promyelocytic cells
Authors: Triana Mendez,Jorge 
Lopez Sanchez,Mariana 
Rico, Milagros 
González-Platas, Javier
Quintana, J 
Estevez, F 
León, Francisco
Bermejo, Jaime
UNESCO Clasification: 230690 Química de productos naturales orgánicos
Keywords: Lactones
Constituents
Apoptosis
Growth
Assay
Issue Date: 2003
Publisher: 0163-3864
Journal: Journal of Natural Products 
Abstract: Four new compounds, a sesquiterpene, eleganodiol (1), and three sesquiterpene lactones, eleganolactone A (2), eleganolactone B (3), and elegain (4), were isolated from Gonospermum elegans along with 16 known compounds. The structures of 1, 2, and 4 were determined on the basis of MS and NMR studies of their acetate derivatives (1a, 2a, 4a). The structure of the acetate derivative (3a) of 3 was determined on the basis of spectroscopic data interpretation and by single-crystal X-ray diffraction. Compounds 2a and 3a were used to study their biological activities on the HL-60 human promyelocytic leukemia cell line. These compounds induced morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death.
URI: http://hdl.handle.net/10553/47060
ISSN: 0163-3864
DOI: 10.1021/np020390y
Source: Journal Of Natural Products [ISSN 0163-3864], v. 66 (7), p. 943-948
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