Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45951
Title: Impact of obesity in patients infected with 2009 influenza A(H1N1)
Authors: Díaz, Emili
Rodríguez, Alejandro
Martin-Loeches, Ignacio
Lorente, Leonardo
Del Mar Martín, María
Pozo, Juan Carlos
Montejo, Juan Carlos
Estella, Angel
Arenzana, Ángel
Rello, Jordi
Cobo, Pedro
Martins, Javier
Carbayo, Cecilia
Robles-Musso, Emilio
Cárdenas, Antonio
Fierro, Javier
Fernández, Ocaña
Sierra, Rafael
Huertos, Ma Jesús
Guerrero, R.
Márquez, Enrique
Rodríguez-Carvajal, Manuel
Jareño, Antonio
Pomares, José
Ballesteros, José Luis
Fernández, Yolanda
Lobato, Francisco
Prieto, José F.
Albofedo-Sánchez, José
Martínez, Pilar
Castellanos, Miguel Angel Díaz
Sevilla, Guillermo
Garnacho-Montero, José
Hinojosa, Rafael
Fernández, Esteban
Loza, Ana
León, Cristóbal
Ocaña, Dolores
Avellanas, Manuel Luis
Lander, Arantxa
De Arellano, S. Garrido Ramírez
Lacueva, M. I.Marquina
Luque, Pilar
González, Ignacio
Montón, Jose Ma
Díaz, Jose Ma
López-Reina, Pilar
Sáez, Sergio
Iglesias, Lisardo
González, Carmen Pascual
Quiroga
García-Rodríguez, Águeda
Socias, Lorenzo
Ibánez, Pedro
Borges-Sa, Marcío
Socias, A.
Del Castillo, A.
Marcos, Ricard Jordà
Bonell, José M.
Amestarán, Ignacio
Ruiz-Santana, Sergio 
Díaz, Juan José
Sisón
Hernández, David
Trujillo, Ana
Regalado, Luis
Martín, Mar
Martínez, Sergio
Cáceres, J. J.
Suberviola, Borja
Ugarte, P.
García-López, Fernando
Alonso, Angel Álvaro
Pasilla, Antonio
Grande, Ma Luisa Gómez
Albaya, Antonio
Canabal, Alfonso
Marina, Luis
Messa, Juan B.López
Pueyo, Ma Jesús López
Ferreras, Zulema
Macias, Santiago
Berezo, José Ángel
Varela, Jesús Blanco
Andaluz, Ojeda A.
Terrero, Antonio Álvarez
Ezpeleta, Fabiola Tena
Catalán, Rosa Ma
Ferrer, Miquel
Torres, Antoni
Barbadillo, Sandra
UNESCO Clasification: 32 Ciencias médicas
320505 Enfermedades infecciosas
Keywords: Obesity
Influenza A
H1N1
Issue Date: 2011
Journal: Chest (American College of Chest Physicians) 
Abstract: Objective: A large proportion of patients infected with 2009 influenza A(H1N1) (A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality. Methods: This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A(H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI > 30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P < .05 were considered significant. Results: In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI > 40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P < .01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P = .02), had longer ICU length of stay (10.8 ± 12.1 days vs 13.7 ± 11.7 days, P = .03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P = .02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1; 95% CI, 0.69-1.75; P = .68). Conclusions: In our cohort, patients who were obese and infected with A(H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.
URI: http://hdl.handle.net/10553/45951
ISSN: 0012-3692
DOI: 10.1378/chest.10-1160
Source: Chest [ISSN 0012-3692],v. 139, p. 382-386
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