Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45810
Título: Analysis of anti-inflammatory, analgesic, stimulant and antidepressant drugs in purified water from wastewater treatment plants using SPE-LC tandem mass spectrometry
Autores/as: Afonso-Olivares, Cristina 
Sosa-Ferrera, Zoraida 
Santana-Rodríguez, José J. 
Clasificación UNESCO: 2301 química analítica
Palabras clave: Pharmaceutical compounds
SPE
LC-DAD
LC-MS/MS
Wastewater
Fecha de publicación: 2012
Publicación seriada: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering 
Resumen: This work presents an effective sample preparation method for the evaluation of seven pharmaceutical compounds belonging to different therapeutic classes in purified water from wastewater treatment plants (WWTPs). The target compounds include caffeine (stimulant), nicotine (stimulant), atenolol (beta blocker), metamizole (anti-inflammatory and analgesic), fluoxetine (antidepressant), paraxanthine (stimulant) and clofibric acid (lipid regulator). Solid-phase extraction (SPE) and liquid chromatography-mass spectrometry (LC-MS) were selected as extraction and detection techniques, respectively. A detailed study of the experimental conditions of extraction was performed. Under optimal conditions, recoveries obtained were in the range of 21% to 100%, and the relative standard deviations were below 12%. The detection and quantification limits of the method were in the range 2.2–97.4 and 21.1–324.7 ng L−1, respectively. The developed method was successfully applied to evaluate the presence of these pharmaceutical compounds in wastewaters samples from wastewater treatment plants located on the Gran Canaria Island (Spain). Most of the compounds were detected at concentrations up to 12.31 μg L−1 in the WWTP influents that were studied.
URI: http://hdl.handle.net/10553/45810
ISSN: 1093-4529
DOI: 10.1080/10934529.2012.665005
Fuente: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering [ISSN 1093-4529], v. 47 (6), p. 887-895
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