Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45361
Title: Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Authors: Simón Martín,Fernando 
Siles-Lucas, Mar
Morchon Garcia,Rodrigo 
González-Miguel, Javier
Mellado, Isabel
Carretón Gomez, Elena 
Montoya Alonso, José Alberto 
UNESCO Clasification: 240112 Parasitología animal
310907 Patología
Keywords: Dirofilaria immitis
Dirofilaria repens
Dirofilariasis
Dogs
Cats
Humans
Issue Date: 2012
Publisher: 0893-8512
Journal: Clinical Microbiology Reviews 
Abstract: Dirofilariasis represents a zoonotic mosaic, which includes two main filarial species (Dirofilaria immitis and D. repens) that have adapted to canine, feline, and human hosts with distinct biological and clinical implications. At the same time, both D. immitis and D. repens are themselves hosts to symbiotic bacteria of the genus Wolbachia, the study of which has resulted in a profound shift in the understanding of filarial biology, the mechanisms of the pathologies that they produce in their hosts, and issues related to dirofilariasis treatment. Moreover, because dirofilariasis is a vector-borne transmitted disease, their distribution and infection rates have undergone significant modifications influenced by global climate change. Despite advances in our knowledge of D. immitis and D. repens and the pathologies that they inflict on different hosts, there are still many unknown aspects of dirofilariasis. This review is focused on human and animal dirofilariasis, including the basic morphology, biology, protein composition, and metabolism of Dirofilaria species; the climate and human behavioral factors that influence distribution dynamics; the disease pathology; the host-parasite relationship; the mechanisms involved in parasite survival; the immune response and pathogenesis; and the clinical management of human and animal infections.
URI: http://hdl.handle.net/10553/45361
ISSN: 0893-8512
DOI: 10.1128/CMR.00012-12
Source: Clinical Microbiology Reviews [ISSN 0893-8512], v. 25, p. 507-544
Appears in Collections:Reseña
Show full item record

SCOPUSTM   
Citations

358
checked on Feb 28, 2021

WEB OF SCIENCETM
Citations

333
checked on Feb 28, 2021

Page view(s)

51
checked on Feb 28, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.