Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45361
Título: Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Autores/as: Simón Martín,Fernando 
Siles-Lucas, Mar
Morchon Garcia,Rodrigo 
González-Miguel, Javier
Mellado, Isabel
Carretón Gomez, Elena 
Montoya Alonso, José Alberto 
Clasificación UNESCO: 240112 Parasitología animal
310907 Patología
Palabras clave: Dirofilaria immitis
Dirofilaria repens
Dirofilariasis
Dogs
Cats, et al.
Fecha de publicación: 2012
Editor/a: 0893-8512
Publicación seriada: Clinical Microbiology Reviews 
Resumen: Dirofilariasis represents a zoonotic mosaic, which includes two main filarial species (Dirofilaria immitis and D. repens) that have adapted to canine, feline, and human hosts with distinct biological and clinical implications. At the same time, both D. immitis and D. repens are themselves hosts to symbiotic bacteria of the genus Wolbachia, the study of which has resulted in a profound shift in the understanding of filarial biology, the mechanisms of the pathologies that they produce in their hosts, and issues related to dirofilariasis treatment. Moreover, because dirofilariasis is a vector-borne transmitted disease, their distribution and infection rates have undergone significant modifications influenced by global climate change. Despite advances in our knowledge of D. immitis and D. repens and the pathologies that they inflict on different hosts, there are still many unknown aspects of dirofilariasis. This review is focused on human and animal dirofilariasis, including the basic morphology, biology, protein composition, and metabolism of Dirofilaria species; the climate and human behavioral factors that influence distribution dynamics; the disease pathology; the host-parasite relationship; the mechanisms involved in parasite survival; the immune response and pathogenesis; and the clinical management of human and animal infections.
URI: http://hdl.handle.net/10553/45361
ISSN: 0893-8512
DOI: 10.1128/CMR.00012-12
Fuente: Clinical Microbiology Reviews [ISSN 0893-8512], v. 25, p. 507-544
Colección:Reseña
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