Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45334
Title: A straightforward route to obtain 13C1-labeled clenbuterol
Authors: González-Antuña, Ana 
Lavandera, Iván
Rodríguez-González, Pablo
Rodríguez, Julio
García Alonso, José Ignacio
Gotor, Vicente
UNESCO Clasification: 32 Ciencias médicas
230103 Análisis cromatográfico
230110 Espectroscopia de masas
Keywords: β-Agonists
Clenbuterol
Minimal labeling
Friedel–Crafts reaction
13C-Labeling
Issue Date: 2011
Journal: Tetrahedron 
Abstract: Singly-labeled 13C1-clenbuterol has been synthesized employing a straightforward pathway starting from easily available acetanilide. The critical step was the Friedel–Crafts acylation of this compound with marked acetyl chloride, being the first example of the use of this methodology applied to the synthesis of a clenbuterol derivative. Subsequent chemical reactions afforded the desired product with good yields.
URI: http://hdl.handle.net/10553/45334
ISSN: 0040-4020
DOI: 10.1016/j.tet.2011.05.118
Source: Tetrahedron [ISSN 0040-4020], v. 67, p. 5577-5581 (Agosto 2011)
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