Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43743
Title: Prevalence and risk factors for non-vertebral fractures in patients receiving oral glucocorticoids
Authors: Sosa Henríquez, Manuel José 
Jesus, Gomez de Tejada Romero Maria
Saavedra Santana, Pedro 
Antonio, Blazquez Cabrera Jose
Alberto, Garcia Vadillo Jesús
Carmen, Valdes Llorca
Manuel, Diaz Curiel
Manuel, Munoz Torres
Elena, Martinez Rodriguez Maria
Carmen, Navarro Ceballos
Jose, Sanfelix Genoves
Jesus, Cancelo Hidalgo Maria
Pedro, Carpintero Benitez
Manuel, Mesa Ramos
Santiago, Palacios Gil Antunano
Cancelo Hidalgo, Maria Jesus
Curiel, Manuel Diaz
Ramos, Manuel Mesa
Torres, Manuel Muñoz
Carpintero, Pedro
Ceballos, Carmen Navarro
Genoves, Jose Sanfelix
Llorca, Carmen Valdesy
Cabrera, Jose Antonio Blazquez
Rodriguez, Maria Elena Martinez
Vadillo, Alberto Garcia
Bilbao, Jose Luis Neyro
Alvarez, Maria Jesus Moro
Eslava, Antonio Torrijos
Novoa, Xurso
Gimeno, Esteban Jodar
Fernandez, Ines Luque
Guerra, Guillermo Martinez Diaz
Gomez, Jose Manuel Quesada
Moreno, Pedro Rozas
Herrero, Alvaro Casas
Formiga, Francesc
Gonzalez, Teresa
Gonzalo, Maria
Lazaro, Montserrat
Lampre, Pilar Mesa
Rubio, Josep Blanch
del Pino Montes, Javier
Saidler, Leonardo Mellivobsky
Lopez, Pilar Orozco
Silva, Lucia
Vilaseca, Daniel Roig
Alvarez, Salvador
Bejar, Milagros Gonzalez
Jimeno, Maria Jose
Rabaneda, Silvia Dorado
Ruiz, Vicente Giner
Vazquez, Fernando Leen
Berenguer, Inmaculada Pereiro
Martin, Alvaro Perez
Varela, Nidia Ruiz
Varilla, Alejandro Tejedor
Negrin, Francisco Vargas
Salinas, Rosa Bautista
Calvo Hernandez, Luz Marina 
de Escalante Yangüe, Begona
Rubio, Jose Filgueira
Galindo Andugar, Maria Angeles
Leon, Rocio Gonzalez
Hernandez Hernandez, Jose Luis
Hernandez, Diego Hernandez
Lopez-Herce Cid, Jose Andres
Val Martin Sanz, Maria del
Pacheco, Elena Molina
Martinez, Amalia Navarro
Solan, Xavier Noguesi
Centeno, Norberto Ortego
Perez Castrillon, Jose Luis
Pinilla, Blanca
Molini, Pilar Sanchez
Cabrera, Mercedes Suarez
Miranda, Raimundo Tirado
Vazquez Gamez, Maria Angeles
Raluy, Marcelo Calabozo
Espadaler, Luis
Espino, Pilar
Melon, Julia Fernandez
Ariste, Jordi Fiter
Sanchez, Elena Garmendia
Gonzalez Hernandez, Maria Teresa
Dominguez, Jose Gonzalez
Polo, Javier Gonzalez
Manrique, Sara
Oyarzabal, Irigoyen
Alvarez, Enrique Raya
Diaz, Monica Vazquez
Retortillo, Mirian Gutierrez
Vega, Soraya Hijazi
Cabrera, Francisco Luna
Vazquez, Xoan Miguens
Antonio, Juan
Fernandez, Olmo
Arrebola, Andres Pena
Cristina, Maria
UNESCO Clasification: 32 Ciencias médicas
Keywords: Adrenal Cortex
Hormones
Osteoporosis
Issue Date: 2012
Publisher: 1726-913X
Journal: International Journal of Endocrinology and Metabolism 
Abstract: Background: Glucocorticoids taken orally increase the risk of fractures. It has been noted that a dose as low as 2.5 mg/day increases the risk of vertebral fracture. What is less clear is the possible influence of other risk factors for osteoporosis on the presence of non-vertebral fractures in patients taking glucocorticoids. Objectives: A cross-sectional study, performed on 513 men and women from Spain, who were taking at least 7.5 mg/day of oral prednisone for a minimum of 3 months. A questionnaire was developed, through which information on risk factors was collected. Patients and Methods: A cross-sectional study, performed on 513 men and women from Spain, who were taking at least 7.5 mg/day of oral prednisone for a minimum of 3 months. A questionnaire was developed, through which information on risk factors was collected. Results: 28.3% of the patients who were taking glucocorticoids at a daily oral dose of 7.5 mg/day for a minimum of 3 months had suffered at least one non-vertebral fracture. The risk increased with age, the number of months the glucocorticoids had been taken, the presence of falls in the last year and, above all, with a maternal history of hip fracture. Conclusions: In patients taking oral glucocorticoids for over 3 months at doses higher than 7.5 mg/day of prednisone or equivalent, the prevalence of non-vertebral fractures was 28.3%. Some risk factors associated with the presence of these fractures were identified. The duration of glucocorticoid use appears to be more strongly related to the presence of non-vertebral fractures than the daily dose.
URI: http://hdl.handle.net/10553/43743
ISSN: 1726-913X
DOI: 10.5812/ijem.3442
Source: International Journal of Endocrinology and Metabolism [ISSN 1726-913X], v. 10, p. 480-485
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