Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43487
Title: Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells
Authors: León, Francisco
Brouard, Ignacio
Rivera, Augusto
Torres, Fernando
Rubio Sánchez, Sara 
Quintana Aguiar, José Martín 
Estévez Rosas, Francisco Jesús 
Bermejo, Jaime
UNESCO Clasification: 32 Ciencias médicas
Keywords: Myeloid-Leukemia Cells
Lanostanoid Triterpenes
Apoptosis
Activation
Induction, et al
Issue Date: 2006
Publisher: 0022-2623
Project: Nuevos Compuestos Antileucémicos 
Journal: Journal of Medicinal Chemistry 
Abstract: Two new long-chain ceramides, trametenamides A (1) and B (2), were isolated from the methanolic extract of the fruiting body of the fungus Trametes menziesii. The structures were elucidated by spectroscopic analyses and chemical transformations, and the absolute stereochemistry of trametenamide B (2) was determined by stereoselective total synthesis of four possible diastereomers. The acetyl derivative of the natural ceramide (1a) and synthetic ceramides (24−27) showed cytotoxicity on the human melanoma cell line SK-MEL-1, which was caused by induction of apoptosis as determined by DNA fragmentation, poly(ADP-ribose) polymerase cleavage, and procaspase-9 and -8 processing.
URI: http://hdl.handle.net/10553/43487
ISSN: 0022-2623
DOI: 10.1021/jm0605334
Source: Journal Of Medicinal Chemistry [ISSN 0022-2623], v. 49 (19), p. 5830-5839
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