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| Title: | Synthesis of novel spirostanic saponins and their cytotoxic activity | Authors: | Hernández, Juan C. León, Francisco Brouard, Ignacio Torres, Fernando Rubio Sánchez, Sara Quintana Aguiar, José Martín Estévez Rosas, Francisco Jesús Bermejo, Jaime |
UNESCO Clasification: | 32 Ciencias médicas | Keywords: | Synthesis Spirostanic saponins Cytotoxicity Apoptosis Leukemia, et al |
Issue Date: | 2008 | Publisher: | 0968-0896 | Journal: | Bioorganic and Medicinal Chemistry | Abstract: | This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds. | URI: | https://accedacris.ulpgc.es/handle/10553/43483 | ISSN: | 0968-0896 | DOI: | 10.1016/j.bmc.2007.10.089 | Source: | Bioorganic & Medicinal Chemistry [ISSN 0968-0896], v. 16 (4), p. 2063-2076 |
| Appears in Collections: | Artículos |
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