Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/42997
Título: Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules
Autores/as: Luo, Shouqing
Garcia-Arencibia, Moises 
Zhao, Rui
Puri, Claudia
Toh, Pearl P.C.
Sadiq, Oana
Rubinsztein, David C.
Clasificación UNESCO: 32 Ciencias médicas
Fecha de publicación: 2012
Editor/a: 1097-2765
Publicación seriada: Molecular Cell 
Resumen: Bim is a proapoptotic BH3-only Bcl-2 family member. In response to death stimuli, Bim dissociates from the dynein light chain 1 (DYNLL1/LC8), where it is inactive, and can then initiate Bax/Bak-mediated mitochondria-dependent apoptosis. We found that Bim depletion increases autophagosome synthesis in cells and in vivo, and this effect is inhibited by overexpression of cell death-deficient Bim. Bim inhibits autophagy by interacting with Beclin 1, an autophagy regulator, and this interaction is facilitated by LC8. Bim bridges the Beclin 1-LC8 interaction and thereby inhibits autophagy by mislocalizing Beclin 1 to the dynein motor complex. Starvation, an autophagic stimulus, induces Bim phosphorylation, which abrogates LC8 binding to Bim, leading to dissociation of Bim and Beclin 1. Our data suggest that Bim switches locations between apoptosis-inactive/autophagy-inhibitory and apoptosis-active/autophagy-permissive sites.
URI: http://hdl.handle.net/10553/42997
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2012.05.040
Fuente: Molecular Cell [ISSN 1097-2765], v. 47, p. 359-370
Colección:Artículos
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