Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35366
Title: Retrospective evaluation of COX-2 expression, histological and clinica lundergoing nephrectomy
Authors: Carvalho, S.
Stoll, A. L.
Priestnall, S. L.
Suárez-Bonnet, A. 
Rassnick, K.
Lynch, S.
Schoepper, I.
Romanelli, G.
Buracco, P.
Atherton, M.
De Merlo, E. M.
Lara-Garcia, A.
UNESCO Clasification: 3109 Ciencias veterinarias
Keywords: Canine renal cell carcinoma
Chemotherapy
COX-2 expression
Histologictype
Metastasis
Mitotic index
Poorly differentiated tubular
Issue Date: 2017
Journal: Veterinary and Comparative Oncology 
Abstract: Limited veterinary literature is available regarding prognostic markers for canine renal cell carcinoma (CRCC). We retrospectively evaluated COX-2 expression, histological and clinical features associated with prognosis of CRCC. Sixty-four cases post-nephrectomy were included, 54 had histopathological assessment and 30 had COX-2 immunostaining performed. Eight dogs (13\%) had metastatic disease at initial diagnosis. Twenty-seven dogs (42\%) received adjuvant therapy after nephrectomy. On univariate analysis, COX-2 expression, mitotic index (MI), histologic type, vascular invasion, neoplastic invasiveness and metastasis at diagnosis were significantly associated with overall median survival time (MST). COX-2 score (COX-2 score > 3 MST 420 days versus 1176 days if cox-2 score < 3; p = 0.011) and MI (MI > 30 MST 120 days versus 540 days for mi < 30; p = 0.003) were the only variables associated with CRCC outcome on multivariate analysis. The addition of MI and COX-2 immunostaining to standard histopathological evaluation would help predicting outcome in CRCC patients.
URI: http://hdl.handle.net/10553/35366
ISSN: 1476-5810
DOI: 10.1111/vco.12264
Source: Veterinary and Comparative Oncology [ISSN 1476-5810], v. 15 (4), p. 1280-1294
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

4
checked on Apr 4, 2020

WEB OF SCIENCETM
Citations

3
checked on Apr 4, 2020

Page view(s)

1
checked on Apr 4, 2020

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.