Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/132579
Título: Serum cholesterol levels are inversely associated with the risk of malignancy in subjects with Bethesda category IV thyroid nodules
Autores/as: Montejo-Marcos, Beatriz
Lopez Plasencia,Yaiza 
Marrero Arencibia,Dunia 
Rodriguez-Perez, Carlos A.
Boronat Cortés, Mauro 
Clasificación UNESCO: 3206 Ciencias de la nutrición
320502 Endocrinología
Palabras clave: Cancer-Risk
System
Cytopathology
Thyroid
Follicular Neoplasm, et al.
Fecha de publicación: 2024
Publicación seriada: Endocrinologia Diabetes Y Nutricion 
Resumen: Introduction: Some epidemiological data suggest that there may be an inverse relationship between cholesterol levels and the risk of thyroid cancer in the overall population. The present study was aimed to evaluate the lipid profile specifically in subjects with Bethesda category IV thyroid nodules, and compare whether there were any differences between those with benign and malignant nodules. Methods: Single-centre, retrospective study on 204 subjects treated by partial or total thyroidectomy for excision of a Bethesda category IV thyroid nodule, who had undergone a blood lipid profile test in the 12 months prior to surgery. In addition to lipid measures, other demographic, clinical, biochemical and ultrasound data were collected. Results: Seventy-five subjects (36.8%) were diagnosed with thyroid carcinoma in the definitive histopathological examination. Patients with thyroid cancer had lower levels of total cholesterol, LDL-cholesterol and non-HDL-cholesterol than subjects with benign thyroid diseases. There were no differences in HDL-cholesterol, triglycerides or total cholesterol/HDL-cholesterol ratio. There were no differences either between groups in other clinical, biochemical and ultrasound variables, including the use of lipid-lowering drugs. In multivariate analysis, only LDL-cholesterol was independently associated with malignancy. Subjects with follicular carcinoma showed the lowest cholesterol levels, while those with papillary carcinoma had intermediate values between the group with follicular carcinoma and the group with benign thyroid diseases. Conclusions: In subjects with cytologically indeterminate Bethesda category IV thyroid nodules, levels of total cholesterol, non-HDL-cholesterol and, particularly, LDL-cholesterol are lower among those with malignant nodules.
URI: http://hdl.handle.net/10553/132579
ISSN: 2530-0180
DOI: 10.1016/j.endinu.2024.03.007
Fuente: Endocrinologia Diabetes Y Nutricion [ISSN 2530-0180], v. 71 (6), p. 246-252, (Junio-Julio 2024)
Colección:Artículos
Vista completa

Visitas

16
actualizado el 23-sep-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.