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http://hdl.handle.net/10553/130496
Título: | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children | Autores/as: | Bastard, Paul Gervais, Adrian Taniguchi, Maki Saare, Liisa Sarekannu, Karita Le Voyer, Tom Philippot, Quentin Rosain, Jeremie Bizien, Lucy Asano, Takaki Garcia-Prat, Marina Parra-Martinez, Alba Migaud, Melanie Tsumura, Miyuki Conti, Francesca Belot, Alexandre Riviere, Jacques G. Morio, Tomohiro Tanaka, Junko Javouhey, Etienne Haerynck, Filomeen Duvlis, Sotirija Ozcelik, Tayfun Keles, Sevgi Tandjaoui-Lambiotte, Yacine Escoda, Simon Husain, Maya Pan-Hammarstrom, Qiang Hammarstrom, Lennart Ahlijah, Gloria Haidar, Anthony Abi Soudee, Camille Arseguel, Vincent Abolhassani, Hassan Sahanic, Sabina Tancevski, Ivan Nukui, Yoko Hayakawa, Seiichi Chrousos, George P. Michos, Athanasios Tatsi, Elizabeth-Barbara Filippatos, Filippos Rodriguez-Palmero, Agusti Troya, Jesus Tipu, Imran Meyts, Isabelle Roussel, Lucie Ostrowski, Sisse Rye Schidlowski, Laire Prando, Carolina Condino-Neto, Antonio Cheikh, Nathalie Bousfiha, Ahmed A. El Bakkouri, Jalila Peterson, Part Pujol, Aurora Levy, Romain Quartier, Pierre Vinh, Donald C. Boisson, Bertrand Beziat, Vivien Zhang, Shen-Ying Borghesi, Alessandro Pession, Andrea Andreakos, Evangelos Marr, Nico Mentis, Alexios-Fotios A. Mogensen, Trine H. Rodríguez Gallego, José Carlos Soler-Palacin, Pere Colobran, Roger Tillmann, Vallo Neven, Benedicte Trouillet-Assant, Sophie Brodin, Petter Abel, Laurent Jouanguy, Emmanuelle Zhang, Qian Martinon-Torres, Federico Salas, Antonio Gomez-Carballa, Alberto Gonzalez-Granado, Luis I. Kisand, Kai Okada, Satoshi Puel, Anne Cobat, Aurelie Casanova, Jean-Laurent |
Clasificación UNESCO: | 32 Ciencias médicas 320505 Enfermedades infecciosas |
Palabras clave: | Anticytokine Autoantibodies Human Interferon Patient Autoimmunity Infection, et al. |
Fecha de publicación: | 2024 | Publicación seriada: | Journal of Experimental Medicine | Resumen: | We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2. | URI: | http://hdl.handle.net/10553/130496 | ISSN: | 0022-1007 | DOI: | 10.1084/jem.20231353 | Fuente: | Journal Of Experimental Medicine[ISSN 0022-1007],v. 221 (2), (Febrero 2024) |
Colección: | Artículos |
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