Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/130493
Título: 2-Hydroxyethyl methacrylate (2-HEMA) sensitization, a global epidemic at its peak in Spain?
Autores/as: Gatica-Ortega, Maria Elena
Pastor-Nieto, Maria Antonia
Gimenez-Arnau, Ana Maria
Mercader-Garcia, Pedro
Sanz-Sanchez, Tatiana
Carrascosa-Carrillo, Jose Manuel
Cordoba-Guijarro, Susana
Sánchez Pérez, Javier
Silvestre, Juan Francisco
Frutos, Francisco Javier Ortiz-de
Tous-Romero, Fatima
Fernandez-Redondo, Virginia
Serra-Baldrich, Esther
Ruiz-Gonzalez, Inmaculada
Perez, Ricardo Gonzalez
Miquel-Miquel, Javier
Guillen, Paloma Sanchez-Pedreno
Hervella-Garcia, Marcos
Heras-Mendaza, Felipe
Gomez-de-la-Fuente, Enrique
Zaragoza-Ninet, Violeta
Gilo, Araceli Sanchez
Rodriguez-Serna, Mercedes
Mele-Ninot, Gemma
Descalzo, Miguel angel
de-Vega, Marina
Garcia-Doval, Ignacio
Borrego Hernando, Leopoldo 
Clasificación UNESCO: 32 Ciencias médicas
320106 Dermatología
Palabras clave: Allergic Contact-Dermatitis
Acrylates
(Meth)Acrylates
2-Hydroxyethyl Methacrylate
Acrylates, et al.
Fecha de publicación: 2024
Publicación seriada: Contact Dermatitis 
Resumen: Background: A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products. Objectives: To evaluate the frequency of sensitization to 2-hydroxyethyl methacrylate (2-HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates. Methods: From January 2019 to December 2022, 2-HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres. ResultsSix thousand one hundred thirty-four patients were consecutively patch tested with 2-HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable 'occupational' was found to be significantly associated with a higher risk for relevant positive reactions to 2-HEMA (OR: 10.9; 95% CI: 8.1-14.9). Conclusion: (Meth)acrylate sensitization is a prevalent health issue in Spain. 2-HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.
URI: http://hdl.handle.net/10553/130493
ISSN: 0105-1873
DOI: 10.1111/cod.14520
Fuente: Contact Dermatitis[ISSN 0105-1873],v. 90 (5), p. 507-513, (Mayo 2024)
Colección:Artículos
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