Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/128787
Título: p190 <i>BCR-ABL</i> rearrangement in chronic myeloid leukemia and acute lymphoblastic leukemia
Autores/as: Lemes, A.
Casares, MTG
De La Iglesia Íñigo, Silvia Narcisa 
Matutes, E
Molero Labarta, María Teresa 
Clasificación UNESCO: 32 Ciencias médicas
320708 Hematología
Fecha de publicación: 1999
Publicación seriada: Cancer Genetics and Cytogenetics 
Resumen: A minority of chronic myeloid leukemia (CML) cases have breakpoint in the minor cluster region (m-bcr) of the BCR-ABL fusion gene. We report a patient with Ph-positive acute lymphoblastic leukemia and m-bcr breakpoint at diagnosis. The patient was treated with chemotherapy followed by an autologous peripheral blood stem cell transplantation, achieving a clinical and hematological complete remission but with persistence of the Philadelphia chromosome. One year later, she developed leukocytosis with a blood picture consistent with CML. She was treated with hydroxyurea and interferon α with no response. This is the second case of m-bcr CML reported presenting with features of lymphoid blast crisis or acute lymphoblastic leukemia.
URI: http://hdl.handle.net/10553/128787
ISSN: 0165-4608
DOI: 10.1016/s0165-4608(99)00014-x
Fuente: Cancer Genetics and Cytogenetics [0165-4608]. v. 113(1), p. 100-102 (agosto 1999)
Colección:Artículos
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