Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/124189
Título: Usefulness of NT-proBNP in dogs with heartworm: could this biomarker be useful to evaluate pulmonary hypertension?
Autores/as: Costa Rodríguez, Noelia 
García Rodríguez, Sara Nieves 
Matos Rivero, Jorge Isidoro 
Falcón Cordón, Yaiza 
Morchón, Rodrigo
Montoya Alonso, José Alberto 
Carretón Gómez, Elena 
Clasificación UNESCO: 310904 Medicina interna
Palabras clave: Animal Diseases
Biomarker
Dirofilaria Immitis
Dogs
Endarteritis, et al.
Fecha de publicación: 2023
Publicación seriada: Parasites and Vectors 
Resumen: Background: In recent years, the usefulness of echocardiography and serum biomarkers in the diagnosis of pulmonary hypertension (PH) in dogs with heartworm disease has been studied. Previously, N-terminal pro B-type natriuretic peptide (NT-proBNP) has shown high concentrations in dogs with heart disease and/or PH as well as its usefulness as a prognostic indicator, but it has never been evaluated in the diagnosis and prognosis of PH in dogs with heartworm disease. The aim was to evaluate the serum concentrations of NT-proBNP in dogs infected by Dirofilaria immitis to determine its usefulness as a tool to detect precapillary PH. Methods: NT-proBNP was determined in 50 heartworm-infected dogs. Presence/absence of PH was determined echocardiographically, using the Right Pulmonary Artery Distensibility Index (RPAD Index) and the systolic flow of tricuspid regurgitation mainly, together with other echocardiographic measurements following the guidelines of the American College of Veterinary Internal Medicine (ACVIM) for the diagnosis of PH. Other epidemiological parameters (breed, age, sex, status: client-owned or shelter dogs) and clinical parameters (microfilaremia, parasite burden, presence of symptoms, body condition) were collected as well. Results: Moderate-severe PH was present in 40% of the dogs (RPAD Index < 29.5%), NT-proBNP concentrations being significantly higher compared with dogs that did not have PH. A cutoff for NT-proBNP of ≥ 1178.45 pmol/l showed a sensitivity of 64.3% and a specificity of 95.5% for the presence of moderate-severe PH. Older dogs and dogs from shelters showed significantly higher NT-proBNP concentrations. Dogs with symptoms and low body condition presented significantly higher NT-proBNP concentrations as well. Conclusions: The determination of NT-pro-BNP concentration can be a useful tool in the diagnostic work-up of dogs with heartworm disease and associated PH and can help to identify animals in the more advanced stage of this disorder. Graphical abstract: [Figure not available: see fulltext.].
URI: http://hdl.handle.net/10553/124189
ISSN: 1756-3305
DOI: 10.1186/s13071-023-05873-3
Fuente: Parasites and Vectors[EISSN 1756-3305],v. 16 , (Agosto 2023)
Colección:Artículos
Adobe PDF (840,91 kB)
Vista completa

Citas SCOPUSTM   

1
actualizado el 10-nov-2024

Citas de WEB OF SCIENCETM
Citations

1
actualizado el 10-nov-2024

Visitas

51
actualizado el 04-may-2024

Descargas

15
actualizado el 04-may-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.