Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/119302
Título: Correlation of Anti-Tissue Transglutaminase Antibodies With the Mucosal Changes and IgA Status of Children With Celiac Disease
Autores/as: Donat, Ester
Roca, María
Castillejo, Gemma
Sánchez-Valverde, Félix
García-Burriel, Jose Ignacio
Martínez-Ojinaga, Eva
Eizaguirre, Francisco Javier
Barrio, Josefa
Cilleruelo, Mª Luz
Pérez-Solís, David
Ochoa-Sangrador, Carlos
Vecino-López, Raquel
Miranda-Cid, Mª del Carmen
García-Calatayud, Salvador
Torres-Peral, Ricardo
Juste, Mercedes
Armas, Honorio
Barros-García, Patricia
Leis, Rosaura
Solaguren, Rosa
Salazar, José Carlos
García-Romero, Ruth
Ortigosa, Luis
Peña Quintana, Luis 
Urruzuno, Pedro
Codoñer-Franch, Pilar
Garcia-Casales, Zuriñe
Masiques, Maria Llüisa
Galicia-Poblet, Gonzalo
Crehuá-Gaudiza, Elena
Balmaseda, Elena
Rubio-Santiago, Javier
Polanco-Allué, Isabel
Román-Riechmann, Enriqueta
Ribes-Koninckx, Carmen
Clasificación UNESCO: 32 Ciencias médicas
320503 Gastroenterología
320110 Pediatría
Palabras clave: Diagnosis
Multicenter study
Registry
Serology
Fecha de publicación: 2022
Publicación seriada: Journal of Pediatric Gastroenterology and Nutrition 
Resumen: Objectives: The objective of this study was to assess the association between serological markers and changes of the intestinal mucosa in children with celiac disease (CD). Methods: Clinical data from CD patients under 15 years old were collected from the participating centers in an on-line multicenter nationwide observational Spanish registry called REPAC-2 (2011-2017). Correlation between anti-tissue transglutaminase antibodies (t-TGA) levels and other variables, including mucosal damage and clinical findings (symptoms, age, and gender), was assessed. Results: A total of 2955 of 4838 patients had t-TGA and a small bowel biopsy (SBB) performed for CD diagnosis. A total of 1931 (66.2%) patients with normal IgA values had a Marsh 3b-c lesion and 1892 (64.9%) had t-TGA Immunoglobulin A (IgA) ≥ 10 times upper limit of normal (ULN). There is a statistically significant association between t-TGA IgA levels and the degree of mucosal damage ( P < 0.001), the higher the t-TGA IgA levels the more severe the mucosal damage. Those patients who reported symptoms had more severe mucosal damage ( P = 0.001). On the contrary, there was a negative association between age and changes of the intestinal mucosa ( P < 0.001). No association was found with gender. Regarding the IgA-deficient patients, 47.4% (18 cases) had t-TGA Immunoglobulin A (IgA) ≥ 10 times ULN and a Marsh 3b-c lesion was observed in 68.4% (26 patients). No statistical relation was found between t-TGA IgG levels and the changes of the intestinal mucosa, neither a relation with age, gender, or symptoms. Conclusions: There is a positive correlation between t-TGA IgA levels and the severity of changes of the intestinal mucosa. Such correlation was not found in IgA-deficient patients who had positive t-TGA IgG serology. The results in this group of patients support the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition recommendations about the need of performing a SBB in IgA-deficient individuals despite high t-TGA IgG levels.
URI: http://hdl.handle.net/10553/119302
ISSN: 0277-2116
DOI: 10.1097/MPG.0000000000003620
Fuente: Journal of Pediatric Gastroenterology and Nutrition [0277-2116], v. 75(6), p.743-748 (Diciembre 2022)
Colección:Artículos
Vista completa

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.