Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/112279
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Martín-Acosta, Pedro | en_US |
dc.contributor.author | Amesty, Ángel | en_US |
dc.contributor.author | Guerra Rodríguez, Miguel Alfonso | en_US |
dc.contributor.author | Guerra Hernández, Carlos Borja | en_US |
dc.contributor.author | Fernández Pérez, Leandro Fco | en_US |
dc.contributor.author | Estévez-Braun, Ana | en_US |
dc.date.accessioned | 2021-10-18T13:27:53Z | - |
dc.date.available | 2021-10-18T13:27:53Z | - |
dc.date.issued | 2021 | en_US |
dc.identifier.issn | 1424-8247 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/112279 | - |
dc.description.abstract | A set of new dihydro-1H-pyrazolo[1,3-b]pyridine and pyrazolo[1,3-b]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure–activity relationships were outlined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative values | en_US |
dc.language | eng | en_US |
dc.relation | Cribado Farmacológico de Librerías Químicas y Desarrollo Preclínico de Nuevas Entidades Moduladoras de Los Oncogenes Stat3/5 y Yap1, y Del Receptor de Estrógenos (Serm) | en_US |
dc.relation | Aplicación de Una Plataforma de Bioensayos en El Cribado de Bibliotecas Químicas Inspiradas en la Biodiversidad: Identificación y Desarrollo de Moléculas Con Interés Biomédico en Oncología. | en_US |
dc.relation.ispartof | Pharmaceuticals | en_US |
dc.source | Pharmaceuticals [ISSN 1424-8247], v. 14(10), 1026 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 3209 Farmacología | en_US |
dc.subject | 2306 Química orgánica | en_US |
dc.subject.other | Multicomponent reaction | en_US |
dc.subject.other | Embelin | en_US |
dc.subject.other | Antiproliferative activity | en_US |
dc.subject.other | SAR | en_US |
dc.title | Modular Synthesis and Antiproliferative Activity of New Dihydro-1H-pyrazolo[1,3-b]pyridine Embelin Derivatives | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.3390/ph14101026 | en_US |
dc.identifier.issue | 10 | - |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.numberofpages | 29 | en_US |
dc.utils.revision | Sí | en_US |
dc.date.coverdate | Octubre 2021 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 0,851 | |
dc.description.jcr | 5,215 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.esci | ESCI | |
dc.description.miaricds | 10,7 | |
item.fulltext | Con texto completo | - |
item.grantfulltext | open | - |
crisitem.project.principalinvestigator | Fernández Pérez, Leandro Francisco | - |
crisitem.project.principalinvestigator | Guerra Hernández, Carlos Borja | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.orcid | 0000-0002-0047-1131 | - |
crisitem.author.orcid | 0000-0003-4355-5682 | - |
crisitem.author.orcid | 0000-0001-7802-465X | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Guerra Rodríguez, Miguel Alfonso | - |
crisitem.author.fullName | Guerra Hernández, Carlos Borja | - |
crisitem.author.fullName | Fernández Pérez, Leandro Francisco | - |
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