Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/112279
DC FieldValueLanguage
dc.contributor.authorMartín-Acosta, Pedroen_US
dc.contributor.authorAmesty, Ángelen_US
dc.contributor.authorGuerra Rodríguez, Miguel Alfonsoen_US
dc.contributor.authorGuerra Hernández, Carlos Borjaen_US
dc.contributor.authorFernández Pérez, Leandro Fcoen_US
dc.contributor.authorEstévez-Braun, Anaen_US
dc.date.accessioned2021-10-18T13:27:53Z-
dc.date.available2021-10-18T13:27:53Z-
dc.date.issued2021en_US
dc.identifier.issn1424-8247en_US
dc.identifier.urihttp://hdl.handle.net/10553/112279-
dc.description.abstractA set of new dihydro-1H-pyrazolo[1,3-b]pyridine and pyrazolo[1,3-b]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure–activity relationships were outlined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative valuesen_US
dc.languageengen_US
dc.relationCribado Farmacológico de Librerías Químicas y Desarrollo Preclínico de Nuevas Entidades Moduladoras de Los Oncogenes Stat3/5 y Yap1, y Del Receptor de Estrógenos (Serm)en_US
dc.relationAplicación de Una Plataforma de Bioensayos en El Cribado de Bibliotecas Químicas Inspiradas en la Biodiversidad: Identificación y Desarrollo de Moléculas Con Interés Biomédico en Oncología.en_US
dc.relation.ispartofPharmaceuticalsen_US
dc.sourcePharmaceuticals [ISSN 1424-8247], v. 14(10), 1026en_US
dc.subject32 Ciencias médicasen_US
dc.subject3209 Farmacologíaen_US
dc.subject2306 Química orgánicaen_US
dc.subject.otherMulticomponent reactionen_US
dc.subject.otherEmbelinen_US
dc.subject.otherAntiproliferative activityen_US
dc.subject.otherSARen_US
dc.titleModular Synthesis and Antiproliferative Activity of New Dihydro-1H-pyrazolo[1,3-b]pyridine Embelin Derivativesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.3390/ph14101026en_US
dc.identifier.issue10-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages29en_US
dc.utils.revisionen_US
dc.date.coverdateOctubre 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,851
dc.description.jcr5,215
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.esciESCI
dc.description.miaricds10,7
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.project.principalinvestigatorFernández Pérez, Leandro Francisco-
crisitem.project.principalinvestigatorGuerra Hernández, Carlos Borja-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-0047-1131-
crisitem.author.orcid0000-0003-4355-5682-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGuerra Rodríguez, Miguel Alfonso-
crisitem.author.fullNameGuerra Hernández, Carlos Borja-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
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