https://accedacris.ulpgc.es/jspui/handle/10553/30002 Wed, 27 May 2026 07:19:12 GMT 2026-05-27T07:19:12Z https://accedacris.ulpgc.es/jspui/handle/10553/167235 Título: Evaluación mediante rúbricas en ABP audiovisuales: criterios para la valoración de bibliotráiler en “Estéticas y contextos artístico-literarios de la literatura universal” Autores/as: Martínez Sariego, Mónica María Resumen: Las rúbricas son instrumentos críticos en procesos de evaluación, en tanto que proporcionan criterios objetivos para los educadores y establecen expectativas claras para los estudiantes. Este estudio presenta una rúbrica diseñada para la evaluación de bibliotráilers en la asignatura “Estéticas y contextos Artístico-Literarios” del Grado en Lengua Española y Literaturas Hispánicas de la ULPGC. La rúbrica aborda cuatro dimensiones clave: comprensión literaria, creatividad, impacto comunicativo y calidad técnica. Su implementación representa un avance significativo con respecto a anteriores sistemas de evaluación de proyectos similares en la asignatura, en la medida en que posibilita una evaluación objetiva y equitativa, además de ofrecer retroalimentación detallada y constructiva. En el contexto del Aprendizaje Basado en Proyectos (ABP), especialmente en iniciativas audiovisuales como la que aquí presentamos, las rúbricas son vitales para evaluar tanto el proceso creativo como el producto final: facilitan la autoevaluación, promueven la responsabilidad y mejoran las competencias críticas de los estudiantes.; Rubrics are critical instruments in evaluation processes, as they provide objective criteria for educators and set clear expectations for students. This study presents a rubric designed for the evaluation of book trailers in the subject "Aesthetics and Artistic-Literary Contexts" of the Bachelor's Degree in Spanish Language and Hispanic Literatures at ULPGC. The rubric addresses four key dimensions: literary comprehension, creativity, communicative impact, and technical quality. Its implementation represents a significant advancement compared to previous evaluation systems for similar projects in the subject, as it enables objective and equitable evaluation, in addition to offering detailed and constructive feedback. In the context of Project-Based Learning (PBL), especially in audiovisual initiatives like the one presented here, rubrics are vital for evaluating both the creative process and the final product: they facilitate self-assessment, promote responsibility, and improve students' critical skills.; As rubricas são instrumentos críticos nos processos de avaliação, pois fornecem critérios objetivos para os educadores e estabelecem expectativas claras para os estudantes. Este estudo apresenta uma rubrica projetada para a avaliação de book trailers na disciplina "Estéticas e Contextos Artístico-Literários" do curso de Graduação em Língua Espanhola e Literaturas Hispânicas da ULPGC. A rubrica aborda quatro dimensões-chave: compreensão literária, criatividade, impacto comunicativo e qualidade técnica. Sua implementação representa um avanço significativo em comparação com os sistemas de avaliação anteriores para projetos semelhantes na disciplina, na medida em que possibilita uma avaliação objetiva e equitativa, além de oferecer um feedback detalhado e construtivo. No contexto da Aprendizagem Baseada em Projetos (PBL), especialmente em iniciativas audiovisuais como a apresentada aqui, as rubricas são vitais para avaliar tanto o processo criativo quanto o produto final: facilitam a autoavaliação, promovem a responsabilidade e melhoram as competências críticas dos estudantes. Thu, 01 Jan 2026 00:00:00 GMT https://accedacris.ulpgc.es/jspui/handle/10553/167235 2026-01-01T00:00:00Z https://accedacris.ulpgc.es/jspui/handle/10553/167234 Título: Antioxidant, antibacterial, and immunostimulatory potentials of terrestrial and marine extracts from by-products and low-value biomass: an ex vivo study in gilthead seabream (Sparus aurata) head kidney leukocytes Autores/as: Molina Roque, Luis; Acosta Arbelo, Félix Antonio; Izquierdo López, María Soledad; Saromines, Carl John; Grifoll, Vanessa; Docando, Julio; Montero Vítores, Daniel; Torrecillas Burriel, Silvia Resumen: The expansion of aquaculture and the drive toward more sustainable ingredients have promoted the incorporation of alternative and novel raw materials as alternatives to traditional marine raw materials, which can provide bioactive functions in addition to fulfill fish nutritional requirements. In this context, agro-industrial by-products and low-value marine biomass emerge as promising sources of antibacterial, immunomodulatory, and antioxidant bioactive compounds. Valorizing these raw materials within a circular economy framework offers the dual benefits of reducing waste and improving fish resilience. This study evaluated nine natural extracts of terrestrial and marine origin as potential functional ingredients for aquaculture. Terrestrial by-product extracts (TE) included pomegranate peel (rich in punicalagin or ellagic acid), citrus fruits, and grape seeds, whereas marine included marine macro- and micro-algal extracts (ME) (Rhodomonas lens, Desmodesmus sp., Osmundea pinnatifida, Gracilaria sp., and Dictyota sp.). Extracts were characterized by determining their total phenolic and flavonoid contents. Antioxidant activity was evaluated using two methods: 2, 2′-Azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and Ferric Reducing Antioxidant Power (FRAP) assays. Antibacterial activity was assessed against Vibrio anguillarum, V. harveyi, and Photobacterium damselae subsp. piscicida. To assess the effects of extracts at cellular level, ex vivo assays were performed on head kidney leukocytes from gilthead seabream (Sparus aurata), evaluating cytotoxicity, respiratory burst, phagocytic activity, and peroxidase activity. TE showed higher levels of both phenolic compounds and flavonoids than ME, which are usually related to higher antioxidant activity. In addition, TE showed stronger antibacterial effects against the three pathogenic bacteria tested. However, ME in general terms, presented higher immunomodulatory potential, causing respiratory burst activation or higher peroxidase activity in leukocytes. These findings highlight distinct bioactivities depending on extract origin, suggesting that future in vivo studies evaluating the combined use of terrestrial and marine extracts may be of interest to explore potential complementary effects in aquaculture species such as Sparus aurata Thu, 01 Jan 2026 00:00:00 GMT https://accedacris.ulpgc.es/jspui/handle/10553/167234 2026-01-01T00:00:00Z https://accedacris.ulpgc.es/jspui/handle/10553/167233 Título: Health Counseling for Self-Care in Adolescent and Young Women During Pregnancy and Motherhood: A Systematic Review and Meta-Analysis Autores/as: Rodríguez Santiago, Carla; González De La Torre, Héctor; Díaz González, Candelaria Merced; Mies-Padilla, Sergio; Rodríguez Suárez, Claudio Alberto Resumen: This study aimed to evaluate the effectiveness of counseling and educational interventions delivered during pregnancy and early motherhood in promoting maternal health knowledge, self-care behaviors, and related health outcomes among adolescent and young women. A systematic review of randomized controlled trials and quasi-experimental studies published in English or Spanish was conducted using Medline, Web of Science, Scopus, Cinahl, and the Cochrane Library. Methodological quality was assessed using Joanna Briggs Institute critical appraisal tools, and risk of bias was evaluated using the Risk-of-Bias 2 and ROBINS-I tools. Data were synthesized narratively and in tables. When comparable outcomes were reported, preliminary meta-analyses were performed using standardized mean differences with random-effects models. The certainty of evidence was assessed using the GRADE approach. Seven studies (n = 7) involving 776 participants were included. Interventions consisted of counseling or educational programs delivered through face-to-face sessions, group activities, or digital resources. Overall, the interventions were associated with improvements in pregnancy-related knowledge, self-care behaviors, psychological outcomes, and maternal health practices and attitudes; however, the certainty of evidence was low to very low and a high risk of bias was identified across studies. Meta-analysis suggested a possible beneficial effect favoring the intervention for pregnancy-related health knowledge (SMD = 1.90; 95% CI: −0.02 to 3.83) and self-care behaviors (SMD = 2.39; 95% CI: 0.29 to 4.49), although substantial heterogeneity was observed. Counseling and educational interventions during pregnancy may contribute to improvements in pregnancy-related health knowledge and self-care among pregnant adolescents and young women; however, the current evidence is limited and of low certainty. Further well-designed studies conducted in diverse settings are needed to confirm these findings and strengthen the evidence base Thu, 01 Jan 2026 00:00:00 GMT https://accedacris.ulpgc.es/jspui/handle/10553/167233 2026-01-01T00:00:00Z https://accedacris.ulpgc.es/jspui/handle/10553/167232 Título: Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial Autores/as: Pálizas, Fernando; Lattanzio, Bernardo; Durandal, Natalia; Alonso, Maria Eugenia; Duque, Julio; Falcon, Nicolas; Arteaga Mesa,Ruben; Hunter, Martin; Pozo, Mario; Gutierrez, Facundo; Sac, Santiago; Goette, Nicole; Consalvo, Sebastián; Zamudio, Pilar; Bettini, Lisandro; Ibarzabal, Juan Ignacio; Torres, Valentin; Fiorilli, Federico; Sacchi, Walter; Avila, Valentin; Gonzalez, Cecilia; Traverso, Agustin; Lopipi, Antonella; Sterzer, Giuliana; Rodriguez Louzan, Jesica; Estenssoro, Elisa; Dubin, Arnaldo; Westphal, Glauco; Liguori, Matheus; Tramujas, Lucas; Piotto, Bruna; Romano, Marcelo; Medrano, Fernando; Rola, Philippe; Prager, Ross; Basmaji, John; Hernández, Leonardo; Amigo, Daniel; Barra, Alejandro; Coba, Camilo; Valdivia, Luis; Valdivia, Juan Pablo; Petruska, Edward; Noguera, Roselyn; Sarabia, Claudio; Cid, Maria Alicia; Tapia, Jaime; Camacho González, Felipe; Morales, Felipe; Gomez, Alex; Yarur, Carlos; Segura, Jose; Rosales, Ruth; Pairumani, Ronal; Araya, Carla; Cañon, Eduardo; Vera, Monserrat; Larroulet, Macarena; Gallo, Carlos; Mero, Carlos; Medel, Juan Nicolas; Cornejo, Rodrigo; Montoya, Jorge; Carreño, Nicolás; Illanes, Víctor; Cortés, César; Gonzalez Almonacid, Cecilia; Philp Sandoval, Rose Valerie; Castillo Bascur, Pedro Javier; Colima Mendoza, Renato Andrés; Espinoza Casado, Claudia Beatriz; Morales Valenzuela, Julio Enrique; Orellana Naranjo, Valentina; Chavez Medina, Carlos Enrique; López Valladares, Patricio Santiago; Melo Alarcón, Paulo César; Hernández Diaz, Marcos Andrés; Vallejos Rubilar, Víctor Manuel; Chinchon, Eduardo; Valenzuela, Emilio; Oviedo, Vanessa; Castro, Ricardo; Ulloa, Rodrigo; Bravo Morales, Sebastián; Contreras Aguilera, Roberto; Mondaca, Roberto; Retamal, Jaime; Bruhn, Alejandro; Aguilera, Pablo; Blanco, Juan Pablo; Santis, César; Basoalto, Roque; Uribe Copier, Paz; Godoy Juárez, Catalina; Bruna, Mario; Alfaro, Sebastián; Conlledo, Rodrigo; Cisternas, Liliana; Urbina, Camila; Toledo, Valentina; Pavez Paredes, Nicolás; Gallardo, David; Arancibia Henríquez, José Miguel; Aravena Ibáñez, Florencia; Caniguante Barco, Guillermina; Lobo Villarroel, Nelson; Muñoz Morales, Alex; Ramírez Machuca, German; Rojas Vargas, Javier; Valenzuela Cruz, José Luis; Ebner Álvarez, Matías; Sánchez Valenzuela, Juan E.; Gómez Cornejo, Carlos; Bustamante Garmendia, Carmen; Reyes Velasco, Luis Felipe; Serrano, Cristian Camilo; Carvajal, Katherine; Cáceres, Eder Leonardo; Crispin Aldana, Ana María; Ibáñez, Elsa Daniela; González, Angelica; González Perilla, Gloria Patricia; Rodriguez, Oscar Leonardo; Olivella Gomez, Juan; Molina, Francisco; Ochoa, Alvaro; Rodas, Daniel; Blandón, Carlos; Álvarez, Luis Carlos; Poveda, Claudia; Bautista, Diego Fernando; Vargas, Monica; Zarama, Virginia; Escobar, Elena; Diez, Julio; Carvajal, Sandra; Vargas, Carlos; Arango, María Camila; Revelo, Jorge Armando; Díaz, Carime; Umaña, Mauricio; García, Andrés; Medina, Camilo; Florián Pérez, María Cristina; Caicedo Buitrago, Néstor David; Mora, Santiago; Giraldo, Nelson; Ortiz, Guillermo; Celemin, Carlos Augusto; Alfonso Gamboa, Diana Katherine; Cortes Bravo, Aníbal; Garay, Manual Andres; Rodríguez Castro, Nelson Iván; Rojas, Camilo Andres; Guezguan, Jhonatan Alexander; Lara García, Antonio; Marín, Carlos Alberto; Marquez Galindo, Mauricio; Suarez Cárdenas, Daniel Adolfo; Llinás Medina, Yirley Elena; Rojas, Carlos; Solarte, Mercedes; Martinez, Diego; Melendez, Andres; Lozano, Daniel; Milton, Enrrique; Enrriquez, Jennie; Granda Luna, Vladimir; Escola Brito, Ana; Jativa Baquero, Mijayl; Bravo, Joselyn; Figueroa, Victor; Agualongo, Paul; Viellard-Baron, Antoine; Salama, Guillaume; Mekontso Dessap, Armand; Bagate, François; Meziani, Ferhat; Merdji, Hamid; Monnet, Xavier; Lai, Christopher; Anguel, Nadia; Jacquet-Lagreze, Matthias; Guerci, Philippe; Ait Oufella, Hafid; Joffre, Jérémie; Goury, Antoine; Bertrand, Maxime; Schaller, Stefan; Hunsicker, Oliver; Daum, Nils; Fabig, Leo; Markus, Maximilian; Schiemann, Alexander; Marz, Susanne; Schulz, Sara Susan; Teller, Sebastian; Engmann, Christoph; Arustamyan, Sonya; Jung, Christian; Myatra, Sheila Nainan; Divatia, Jigeeshu Vasishtha; Kulkarni, Atul P.; Patil, Vijaya; Rajput, Abhisheksingh R.; Mujawar, Masood; Gorade, Manoj; Shrivastava, Anjana M.; Khot, Sharayu; Rathod, Kiran; Panhale, Karuna; Phillips, Atul; Gupta, Manu; Sharma, Rijushree; Manavalan, Prince; Sori, Praveen; Aggaawal, Ruchika; Jildal, Monica; Roimi, Michael; Vasscheto, Rosanna; Cortegiani, Andrea; Messina, Antonio; Costantini, Elena; Sanfilippo, Filippo; Al Fares, Abdulrahman; Almumin, Ahmed; Abdulrahman, Aminah; Almousawi, Sayed; Gorduño, Jessica; Hernández-Gilsoul, Thierry; Salgado De la Mora, Moises; Valadez Villegas, Diego Artemio; Aguirre Aguilar, C. Eduardo; Pérez Meléndez, Raúl Eduardo; Estrella Sato, Luis Alberto; Quiñonez Flores, Alejandro; Avila Vazquez, Juan Antonio; Bautista Torres, Luis Emilio; Domínguez Porras, Víctor Antonio; del Moral Díez, Juan José; Vargas Carrillo, Juan Pablo; Carbajal Morelos, Sergio Leonardo; Carrillo Vazquez, Daniel Alberto; Jimenez Franco, Brenda; García González, Héctor Benjamín; Perez Mendez, Ayari; Alonso Martinez, Daniel; Hernandez Ortega, Rosario; Nuñez Saavedra, Isaac; Rojas Castañeda, Estefano; Avila-Rojo, Jose Alonso; Paz-Cortes, Jose Armando; Bautista-Torres, Luis Emilio; Vidal-Mayo, Jose de Jesus; Cienfuegos Ortiz, Daniel; Cassiano Quezada, Fabiola; Huerta Gutiérrez de Velasco, Lily Carolina; Hernández Jasso, Joaquín; Hale Cuenca, Karen; Cornejo Sarmiento, Fernando; Santos Vázquez, Gabriel; Ferman Corral, Hugo Esteban; Cortés Arroyo, Eduardo; Davizon López, Carlos Antonio; Almeida Arvizu, Anahí; Aguilar Lugo Gerez, Juan José; Pérez González, Jorge Arturo; Cabrera Larios, Héctor; Troncoso Ortega, Mariana; Pulido Morales, Diana Isabel; Argaiz, Eduardo R; Ibarra-Estrada, Miguel; Aguirre-Avalos, Guadalupe; López-Pulgarín, José Arnulfo; Chavez-Peña, Quetzalcóatl; Ortiz-Macías, Iris Xóchitl; Gamero-Rodríguez, María José; Gomez-Partida, Carlos Alberto; Jimenez-Pérez, Diego Moisés; Bravo-Lozano, Diana Guadalupe; Brizuela-Santana, Julio César; Rodriguez, Job; Anzures, Daniela; Enríquez, José Emmanuel; Vazquez, Ana Cecilia; Monera, Fernando; Chimal, Angelica del Carmen; Torres Lopez, Lizzeth; Parra, Carlos Omar; Ramos, Adonis; Peregrino Vázquez, Francisco; Velazquez Martinez, Efrain; Zamudio, Paola; Pérez-Nieto, Orlando Ruben; Deloya-Tomas, Ernesto; Mondragón-Labelle, Tania Olga; Phinder-Puente, Marian Elizabeth; Rodríguez-Guevara, Ignacio; Anaya-Silva, Sophia Cristina; Mendiola-Villalobos, Carlos; Gonzalez-Toribio, Raul Arturo; Pozos-Cortes, Karen Pamela; Molina-Galeote, Jhordan; Peña-Juárez, Jorge; de la Torre-Rittscher, Andrea Guadalupe; López-Fermín, Jorge; Carrión-Moya, Jorge Daniel; Olvera-Ramos, María Guadalupe; Castillo-Gutiérrez, Gabriela; Bautista-Aguilar, Gabriela Alejandra; Radillo-Santana, Itzel; Carbajo-Martínez, Susana; Cuéllar-Mendoza, Daniela; Patiño-Arreola, Gabriel; Rayo-Rodríguez, Saúl; Reyes-Monge, Rafael Alfonso; González-Sotelo, Samir; Mendez-Martínez, Lourdes Monserrat; Hernández-Rodríguez, Adilene; Tafolla-Sánchez, Edgar Jesús; Pérez-Gómez, Armando; Henales Ocampo, Alexis Stephano; Toledo Palacios, Hazael Agustin; Carvalho, Catarina; Bento, Daniela; Oliveira, Diogo; Militão, Isabel; Carvalho, João; Barros, Nelson; Carvalho, Sérgio; Paixão, Anusca; Fernandes, Joana; Lameirão, Cristina; Costa, Bárbara; Sousa, Margarida; Al Duhailib, Zainab; Nouri, Samar; Alkhaldi, Fawziah; Aldosari, Hessa Abdulaziz; Galiana, Maria; Navarro Martinez, Jose Alejandro; Toral Toral, Ursula; Ferrero Coloma, Carlos; Pardines Rico, Santiago; Garcia Garcia, Covadonga; Gomez Salinas, Luis; Fornes Riera, Francisca Eugenia; Ramis Mut, Jose Luis; Lopez Gil, Vicente; Romero Torres, Manuel; Avilés García, Eva; Spirina, Maria; Parreño Buedo, Delia; de Nadal, Miriam; Benítez-Cano, Adela; Adalia, Ramon; Ramos, Isabel; Ferraroni, Antonio; Rivera, Lorena; Antelo, Marta; Larrañaga, Leire; Carazo, Jesús; Rivera, Hugo; Mercadal, Jordi; Zattera, Luigi; Muñoz, Guido; Alcon, Amalia; Fervienza, Ana; del Rio, Elena; Palomeque, Andrea; Perdomo Díaz, Juan; Carramiñana, Albert; Jacas, Adriana; Barbeta, Enric; Mellado, Ricard; Marrero, Ramses; Tamayo, Gonzalo; Martinez, Alberto; Peralta, Covadonga; Maroño, María Jesús; Hernández, María; Apodaca, Naiara; Sainz, Iñaki; Ganuza, Eunate; Castelo, Iker; Ormazabal, Xabier; Gonzalez Panigaua, Celia; Carrasquedo Benito, Elisa; Matute González, Adrian; Ondarroa Agirrezabal, Ainhoa; Menéndez Luis, Álvaro; Palacio Echevarría, Arrate; Miguel Sánchez, Carmen; Flores Pelegrín, David; Fernández González, Iker; Ferreira Amador, Jesús; Alarcon, Sergio; Montoto, Fernando; Galarza, Laura; Redondo, Francisco Javier; Baladrón, Victor; Villazala, Ruben; Cuesta, Tatiana; Montenegro, Omar; Faba, Patricia; Redondo, Jorge; Moreno, Remedios; Villanueva, Gracia; Casal López,Ana Belén; Valbuena, Manuel; Garvayo, Fernando; Martin, Margarita; Sánchez, Alejandro; Garcia, Nieves; León, Marina; Arroyo, Juan José; Olmedo, Ana; Perez, Ana; García Romero, José Javier; Miralles, Jaime; Berrio, Diana; Cruz De Mercadal,María Del Carmen; Frade Rodríguez, Laura Del Carmen; Valseca Bueno, Miguel; Garcia, Carlos; Tuero Leon, Gaspar; Padron, Oto Miguel; Ojeda, Nazario; Arencibia, Antonio Jesus; Lopez, Sergio; Rodriguez, Aurelio; Sarmiento, Tatiana; Hernandez, Javier; Carmona, Juan José; Trujillo, Hector; Becerra, Angel; Valencia, Lucia; Arachelly, Carmen; Hernanz, Gema; Gomez, Julio; Cabrera, Leonardo; Jimenez, Pedro; Muiño, Virginia; Prats, Maria; Dominguez, Yurena; Rodriguez, Rayco; Santana Luis, Aitor; Fariña, Roberto; Olmos, Eva; Santiago, Nadia; Baumann, Gisela; Clavijo Hernandez,Yanira; Dominguez, Ancor; Ramos, Arantxa; Cabrera, Edgar Jose; Montesdeoca, Monca; León Del Rosario, Sonia; Perez, Carlos Arturo; Diallo, Rassoul Felipe; Fernandez, Maria Jose; Herrera, Lorena; Olivas, Ana Maria; Iglesias, Palma; Gonzalez, Beatris Rita; Joel, Fabio; Fuentes, Pino; Higuera Miguélez, Eva María; Merino García, Maria; Gonzalez De Castro, Rafael; Marcos Vidal, Jose Miguel; Marcos Contreras, Sergio; García Pérez, Cristina; Cobeta, Pilar; Pestaña, David; Martínez, Nilda; Mira, Adrián; Gil, Diego; Bardi, Tommaso; Azzam, Amal; Acevedo, Ismael; Balvis, Alberto; Arias, Gerardo; Martínez, David; Escobar, Jimena; Encuentra, Marta; Segura, Paula; Rubín, Sofía; Claver, Sara; Salvador, Elisa; Carballo, Marina; Olea, Claudia; Calderón Barajas, Adriana; Benguría Puebla, David; Silva García, Javier; Ramiro Ruiz, Álvaro; Lugo Duarte, Carolina; Levstek, Meta; Saiz Sanchez, Miguel; Zarza Fernandez, Víctor; Garcia Alvarez, Raquel; Gonzalez Serrano, Matilde; Hermira, Ana; Real, María Isabel; Lopez, Eloisa; de la Calle Gil, Isabel; Pascual Cambero, Patricia; Fernández García, Aída; Martin, Borja; Enriquez Gómez, Pablo; Rodriguez, Paula; Xia, Ziyi; Cavero, Jorge; Vigo, Javier; Gil, María Jesus; Ernesto, Celda; Covesa, Elena; Molero, Angel; Lopez, Feliz; Fernandez, María Elena; Ramos, Silvia; Piñeiro Otero, Patricia; Solchaga, Isabel; Calvo García, Alberto; Elvira Rodriguez, Adoración; Ramos Fernández, Rafael; Santidrian Bernal, Sheila Olga; Nieves-Alonso, Jesús; Orts, Mar; Figueroa, Cárlos; García Villabona, Esther; Vallejo Lantero, Carmen; Hernando Santos, Julia; Arribas, David; Expósito Carazo, Sonia; Torrente Pérez, Jara; von Wernitz Teleki, Andrés; Guerra Molina, Iñigo; Martínez Molina, Ana María; Suárez-de-la-Rica, Alejandro; Román Guerrero, Carlos; Gomez Arredondo, Luis Anibal; de Ancos Álvaro, Juan; Puga Carrasco, Carlos; Mjertan, Amadea; Cordón Reche, David; Bakhshaliyeva, Nazrin; Martin, Cristina; Maestre Serantes, Paula; Calderon Jiménez, Alejandro; Estiragues Barreiro, Ana; Ruiz Monaci, Sara; Mejía-Abril, Gina; González Bueno, María Auxiliadora; Abad-Santos, Francisco; Bernardos-Gonzalez, Eva; Vaquero, Luis Mario; Iranzo, Reyes; Fernández-García, Raquel; Ayala Soto, Rocio; Narváez Cubillos, Diana; Veláz Domínguez, Saúl; Oliver Fornies, Pablo; Alvarez, Alberto Juan; Castañón Alonso, María Elena; Fernández Iglesias, Cristina; Baeza Álvarez, Luis Manuel; López Pérez, Marta; Ibáñez Fernández, María Covadonga; Pérez de Arriba, Natalia; Álvarez Arias, Covadonga; Leiva Huerta, Antonio Ramón; Trespalacios Guerra, Ramón; Díaz Reguera, Ana; García González, Nerea; Díaz Castro, Héctor; Varela Rodríguez, Lorena; Álvarez Barrial, Amelia; Mancha Getin, Beatriz; Rodríguez Arias, Lucía; Galán Gutiérrez, Julio Cesar; López Noval, Alba; García Segovia, Juan; Picatto Hernández, Pedro; González Rodríguez, Marta; Vergara Díaz, Paola Beatriz; Brid Castañón, María Teresa; Fernández Suárez, Félix Ezequiel; Rodríguez-Flor Saint-Remy, Sergio; Pérez Díaz, Carmen; Berzal Canga, Elena; Sagrado Quero, Sergio; Vives, Marc; Rubio, Iñigo; Casado, Álvaro; Duilio Gonzalez, Ariel; Hidalgo, Francisco; Echarri, Gemma; Callejas, Raquel; Cara, Carmen; Montero, Pablo; Sala, Carmen; Luque, Marta; Goñi, Leire; Fernandez, Jose Antonio; Garro, Javier; Pedrós, Alfonso; Alonso González, María Concepción; Gómez Viana, Leticia; López Pérez, Angel; Carballo Loureiro, Nuria; González Delgado, Manuel; Villar Arcay, Eva; Ruido Dacal, Raquel; Teruelo, Leticia G.; Ortolá Más, Elena; De La Rosa García, Cristina; Varela, Marina; Domínguez García, David; Amador García, Israel; Pazos Otero, Lucía; González Beltrán, Amelia; Soto Jáquez, Luis Alejandro; Sánchez-Navas Parejo, Marina; Díaz Fernández, Adrián; Piñero Prieto, Daniel; Pereira Esmoriz, Liuva; Rodríguez González, Irina Paula; González Chiale, Gabriela Noemí; Vera González, Alberto; Hernández Bisshopp, Raúl; Guillén Iranzo, Carola; Carmona Garcia, Paula; Pajares, Azucena; Lopez Cantero, Marta; Johannessen López, María Victoria; Polo, Silvia; Rodenas Monteagudo, Miguel Angel; del Mazo, Alvaro; Vidal, Ana; Montero, Maria Jesús; Garcia Cantos, Jose; Ferrer, Carolina; Puig, Jaime; Tatay, José; Hernandéz, Javier; Cervera, Alvaro; Gabaldon, Tanya; Jimenez, Marta; Martinez, Sara; Aguilar Aguilar, Gerardo; Montoya Filardi, Alba; Ruiz Martínez, Breitner Antonio; Devís Peiró, Arnau; Ruiz Zarco, Ana; Jiménez, Pablo Lorenzo; Passariello Fernández, Eduardo; Luzón Martínez, Marta; Martínez Albaladejo, Rosalba; Valero García, Jaume; Hurtado Ruiz, Isabel; Beltrán Piles, Carmen; Segura Marín, Nasara; Florea, Raluca; Romero Vargas, Esther; Carbonell López, José; Monleón López, Berta; Badenes Quiles, Rafael; Savino, Martina; Rico, Jesus; Aldecoa, Cesar; Rodriguez, Almudena; Gudiña, Alvaro; Carrascosa, Andres; Almudi, Daniel; Ruiz de Santos, Eugenio; Garcia Saiz, Irene; Garcia Alvarez, Isabel; Vaquero Perez, Laura; Carazo Valencia, Manuel; Perez Gonzalez, María Rocío; Laita Jimenez, Elena; Barbosa Martin, Cristina; Leal Casado, Laura; Ramos Carrasco, Marta; Arranz, Irene; Laguna, David; Díaz, Alba; Vilas Otero, Mª Elena; Leal Ruiloba, Mª Sonsoles; Miralles-Aguiar, Francisco; Wendel Garcia, Pedro David; Kleinert, Eva-Maria; Steiger, Peter; Hilty, Matthias; Ganter, Christoph; Klinzing, Stephanie; Andermatt, Rea; Unseld, Simone; Huser, Dominic; Müller, Andrea; Ulrich, Yvonne; Hofmänner, Daniel Andrea; Zoller, Bernhard; Lea Iseli, Carmen Michelle; Schaer, Caroline; Enthofer, Katharina; Cottini, Silvia; Hauffe, Till; Camen, Giovanni; Hana, Anisa; Karbach, Michael; Nater, Harald; Ruf, Stefan; Furrer, Florian; Wildbolz, Stella; Lehner-Glückert, Katharina; Bader, Patrick; Schüpbach, Reto; Müller, Mattia; Ostermann, Marlies; Powell-Tuck, Jonah; Walton, Fionnuala; D’Amato, Fabiola; Amaro De Jesus, Beatriz; Hendrie, Eleanor; Cendreda, Benjie; Clark, Emily; Radcliffe, Gillian; Morera Vas, Kyma; Santos, Richelle; Fordyce, Sarah; Sparkes, Simon; Hardman, Elizabeth; Peck, Madeleine; Ahmadnia, Ehsan; Salama, Ibrahim; Gowland, Abigail; Nin, Nicolás; de Almeida Lopes, Marcela; Greenwood, John C.; Moitra, Vivek; Khanna, Ashish; Wilcox, M. Elizabeth; Rietdijk , Wim JR; Ng Gong, Michelle; Dellinger, Phill ; Vincent, Jean-Louis; Hernandez, Glenn; Ospina-Tascón, Gustavo A.; Kattan, Eduardo; Ramasco, Fernando; Orozco, Nicolás; Ramos, Karla; Aldana, Jose Luis; Ferri, Giorgio; Hamzaoui, Olfa; De Backer, Daniel; Teboul, Jean-Louis; Vieillard-Baron, Antoine; Petri Damiani, Lucas; García-Gallardo, Gustavo A.; Morales, Sebastian; Carmona Garcia, Paula; Guerrero Méndez, Rosa María; Pérez-Nieto, Orlando R.; Olea Vielba, Claudia; Ramos, Silvia; Domínguez Montesdeoca, David; David, Sascha; Wendel-Garcia, Pedro D.; Galiana-Ivars, María; Myatra, Sheila Nainan; Cecconi, Maurizio; Amthauer, Macarena; Higuera, Eva; Al Duhalib, Zainab; Rico-Feijoo, Jesús; Ferrer-Gómez, Carolina; Pérez-Carbonell, Ana; Martinez-Castro, Sara; Redondo Calvo, Francisco Javier; Vives, Marc; Sanchez, Hector Fabio; Bilbao, Iñaki; Fernandez, Paula; Al-Fares, Abdulrahman; Benitez-Cano, Adela; Reyes, Luis Felipe; Rodriguez-Guillen, Job H.; Cristino, Ana Vaz; Pendino, Juan Carlos; Alonso-Gonzalez, Maria Concepción; Murias, Gastón; Aguirre-Ávalos, Guadalupe; Calderón Barajas, Zulay Adriana; Zarragoikoetxea, Iratxe; Mendonça dos Santos, Tiago; Vallecilla, Liliana; Martins de Lima, Lucas; Sady, Erica; Alegria, Leyla; Ostermann, Marlies; Bakker, Jan; Biasi Cavalcanti, Alexandre Resumen: Importance: The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective: To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length of hospital stay. Design, Setting, and Participants: This randomized clinical trial was conducted in 86 centers in 19 countries. Patients within the first 4 hours of septic shock were included between March 2022 and April 2025, with last follow-up in July 2025. Interventions: Patients were randomized to undergo CRT-PHR (n = 720), including assessment of pulse pressure, diastolic arterial pressure, fluid responsiveness, and bedside echocardiography, to tailor fluids, vasopressors, and inotropes, vs usual care (n = 747). Main Outcomes and Measures: The primary outcome was a hierarchical composite of mortality, duration of vital support (vasoactives, mechanical ventilation, and kidney replacement therapy), and length of hospital stay assessed at 28 days. A win ratio was calculated for the primary outcome by comparing all possible patient pairs, starting with the first event in the hierarchy and stratified by median APACHE (Acute Physiology and Chronic Health Evaluation) II score at admission. Secondary outcomes were mortality, vital support-free days, and length of hospital stay at 28 days. Results: From 1501 randomized patients, 1467 were included in the primary analysis (mean age, 66 [17] years; 43.3% female). There were 131 131 wins (48.9%) in the CRT-PHR group vs 112 787 (42.1%) in the usual care group for the hierarchical composite primary outcome, with a win ratio of 1.16 (95% CI, 1.02-1.33; P = .04). Individual wins for death were 19.1% vs 17.8%; duration of vital support, 26.4% vs 21.1%; and length of hospital stay, 3.4% vs 3.2% in the intervention vs usual care groups, respectively. Conclusions and Relevance: Among patients with early septic shock, a personalized hemodynamic resuscitation protocol targeting capillary refill time was superior to usual care for the primary composite outcome, primarily due to a lower duration of vital support. Wed, 01 Jan 2025 00:00:00 GMT https://accedacris.ulpgc.es/jspui/handle/10553/167232 2025-01-01T00:00:00Z