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Corrigendum to “LBA67 Perioperative pembrolizumab in early-stage non-small- cell lung cancer (NSCLC): 5-year follow-up from KEYNOTE- 671”

2026-01-01T00:00:00Z

Título: Corrigendum to “LBA67 Perioperative pembrolizumab in early-stage non-small- cell lung cancer (NSCLC): 5-year follow-up from KEYNOTE- 671” Autores/as: Wakelee, H.; Spicer, J.; Gao, S.; Liberman, M.; Tsuboi, M.; Kato, T.; Chen, K. N.; Dooms, C.; Majem, M.; Martinengo, G. L.; Bylicki, O.; Rodríguez Abreu, Delvys; Halmos, B.; Jones, D. R.; Chaft, J.; Reck, M.; Jensen, E.; Keller, S. M.; Samkari, A.; Garassino, M. C. Resumen: The organisers regret that in the original publication an error was introduced into the table. For the Pembro Arm the HR (95% CI) should read 0.74 (0.59-0.92) not 10.74 (0.59—0.92). The corrected table is given below.TablePembro Arm (n = 397)Placebo Arm (n = 400)EFSaMedian (95% CI), mo57.1 (38.0–NR)18.4 (14.8–22.1)5-y rate (95% CI)49.9 (44.6–55.0)26.5 (21.7–31.5)HR (95% CI)0.58 (0.48–0.69)OSMedian (95% CI), moNR (NR–NR)70.7 (53.7–NR)5-y rate (95% CI)64.6 (59.5–69.2)53.6 (48.3–58.6)HR (95% CI)0.74 (0.59–0.92)EFSa HR (95% CI)OS HR (95% CI)StagebII (n = 239)0.52 (0.35–0.76)0.67 (0.43–1.05)III (n = 558)0.58 (0.47–0.72)0.75 (0.58–0.96)PD-L1 TPSb≥50% (n = 266)0.44 (0.31–0.64)0.65 (0.42–1.00)1%–49% (n = 242)0.54 (0.39–0.75)0.67 (0.45–0.99)<1% (n = 289)0.74 (0.55–0.98)0.87 (0.62–1.21)NR, not reached; TPS, tumor proportion score.aPer investigator assessment.bAt baseline. The organisers would like to apologise for any inconvenience caused.

Positive Mild Solutions of A Fractional Boundary Value Problem on the Half-Line

2026-01-01T00:00:00Z

Título: Positive Mild Solutions of A Fractional Boundary Value Problem on the Half-Line Autores/as: Caballero Mena, Josefa; Harjani Saúco, Jackie Jerónimo; Sadarangani Sadarangani,Kishin Bhagwands; Toledo Quintana, Rayco Francisco Resumen: In this paper, we investigate the existence and uniqueness of a mild solution to a fractional boundary value problem involving a Riemann-Liouville type fractional derivative. Our approach is based on the application of a relatively recent fixed point theorem for F\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathcal {F}$$\end{document}-contractions in complete metric spaces, which allows us to work under more general conditions than classical contraction principles. This framework provides a powerful and flexible tool for dealing with nonlocal problems arising in various applied fields. In addition to establishing existence and uniqueness, we demonstrate that, under certain additional assumptions, the mild solution is positive. This qualitative property is of particular interest in real-world applications where negative solutions may lack physical meaning. Finally, to illustrate the theoretical results, we present a concrete example that satisfies all the hypotheses and confirms the main conclusions.

Development of Seawater Reverse Osmosis Configurations for Low- and High-Fouling Feedwaters: A Techno-Economic Review of FilmTec Membranes Performance

2026-01-01T00:00:00Z

Título: Development of Seawater Reverse Osmosis Configurations for Low- and High-Fouling Feedwaters: A Techno-Economic Review of FilmTec Membranes Performance Autores/as: Casañas González, Antonio; León Zerpa, Federico; Ramos Martín, Alejandro Resumen: This work presents the most recent advancements and operational experiences obtained with the large-active-area, high-rejection FilmTec (TM) SW30HR-380 and SW30HR-320 reverse osmosis membrane elements, with particular focus on their techno-economic implications, especially regarding energy demand and potential operational cost reductions. The study also examines fouling prevalence and reviews the latest developments in technical mitigation strategies, with emphasis on the new wide-spacer SW30HR-320 elements designed for open-intake applications. Overall, the findings indicate that these new membrane products constitute an effective option for the design of seawater reverse osmosis systems treating both clean and fouling-prone feedwaters. The techno-economic evaluation demonstrates that the adoption of these elements can enable reductions of approximately 20% in capital expenditures, up to 25% in energy consumption, and up to 4% in cleaning-related costs-including downtime-when the SW30HR-320 is operated under high-fouling feedwater conditions.

Oxygen saturation and mortality for acute pulmonary embolism: multinational retrospective cohort study

2026-01-01T00:00:00Z

Título: Oxygen saturation and mortality for acute pulmonary embolism: multinational retrospective cohort study Autores/as: Jimenez, David; Yusen, Roger D.; Velasco, Juan Manuel; Morillo, Raquel; Muriel, Alfonso; Jara-Palomares, Luis; Bertoletti, Laurent; Hernandez-Blasco, Luis Manuel; Gil Díaz, Aída; Moustafa, Fares; Fidalgo, Angeles; Sadeghipour, Parham; Pham, Khanh Quoc; Bikdeli, Behnood; Monreal, Manuel Resumen: Background: Among patients with acute pulmonary embolism (PE), we aimed to evaluate for an association between oxygen saturation (SatO(2)) and 30-day post-PE mortality. Methods: Between January, 2001 and April, 2025, we conducted a retrospective cohort study of 38,739 non-hypotensive patients with acute PE enrolled from 18 countries in the Registro Informatizado de la Enfermedad Tromboemb & oacute;lica (RIETE) registry. Outcomes included 30-day all-cause and PE-specific mortality. We used hierarchical logistic regression to assess for an association between baseline SatO(2) and outcomes. We aimed to identify optimal SatO(2) cut-off points that maximized sensitivity and specificity in relation to mortality from receiver operating characteristic (ROC) curves. RIETE is registered with ClinicalTrials.gov, NCT02832245. Findings Baseline SatO(2) was significantly associated with mortality, where lower SatO(2) had worse outcomes. Using a reference SatO(2) of >96%, patients in the lower SatO(2) strata had higher rates of all-cause death (odds ratio [OR] 0.96 for SatO(2) 94-96%; 1.23 for SatO(2) 90-93%; and 1.81 for SatO(2) <90%) and PE-related mortality (OR 1.68 for SatO(2) 94-96%; 2.04 for SatO(2) 90-93%; and 3.95 for SatO(2) <90%). The optimal cut-off point to identify patients at low-risk for short-term mortality was SatO(2) of 96% (sensitivity of 86.1% and negative predictive value of 96.7%); while SatO(2) of 90% (specificity of 77.2% and positive predictive value of 7.9%) identified patients at increased risk for mortality. Interpretation Among non-hypotensive patients diagnosed with PE, we found an inverse association between baseline SatO(2) and odds of all-cause and PE-associated mortality over the subsequent 30 days. A SatO(2) cutoff value of 96% for the highest SatO(2) group while breathing room air might help better identify patients with acute PE at low-risk for mortality. Future studies should assess the contribution of SatO2 in addition to established prognosticators to predicting the risk of death.