https://accedacris.ulpgc.es/jspui/handle/10553/30001 2026-06-08T11:43:48Z https://accedacris.ulpgc.es/jspui/handle/10553/168363 Título: Nutritional stress suppresses hepatic antioxidant defenses without affecting inflammatory signaling in periparturient fat-tailed ewes Autores/as: Pazir, Rahim; Zarrin, Mousa; Ahmadpour, Amir; Hernández Castellano, Lorenzo Enrique Resumen: Ruminants experience major metabolic stress during the periparturient period, leading to negative energy balance (NEB), oxidative stress, and inflammation. While NEB is well studied in dairy cows, molecular responses to feed restriction in locally adapted fat-tailed sheep breeds remain unclear. This study aimed to study the effect of phased feed restriction and parturition on hepatic genes related to antioxidant defense, NADPH regeneration, and inflammation in Lori Bakhtiari and Turki Qashqai ewes. Twenty ewes were used in this study. The control group (Ctrl; n=10) received pre- and postpartum diets to meet 100% of the energy requirements. The Feed Restricted group (FR; n=10) received a diet to simulate a sudden energy deficit prepartum and postpartum. Liver biopsies were collected on week -3 and 3 relative to parturition. Pro-inflammatory cytokines (IL-6, IL-8, TNFα) were unaffected by FR or parturition. The hepatic mRNA expression of GCLM remained constant in the FR group but decreased in the Ctrl group postpartum. In addition, GCLM mRNA abundance was lower in the FR group compared to the Ctrl group prepartum, but higher postpartum. The hepatic mRNA expression of SRXN1 increased postpartum in the FR group but remained constant in Ctrl. In addition, SRXN1 showed higher abundance in the FR group than in the Ctrl group both prepartum and postpartum. Both hepatic mRNA expression of GPX3 and GPX4 were constant in the FR group but increased in the Ctrl group postpartum. Thus, no differences in GPX3 and GPX4 were detected between groups prepartum but were lower in the FR group compared to the Ctrl group postpartum. In addition, FR downregulated the hepatic mRNA expression of GCLC, G6PD, 6PGD, CAT, SOD1, and SOD3, while increasing GR1. Parturition decreased the hepatic mRNA expression GCLC, G6PD, 6PGD, and TXNRD1, and increased Hb, SOD1, and SOD3 mRNA abundance. Feed restriction reduced key hepatic antioxidant and NADPH-regenerating genes, while parturition further intensified oxidative processes. Despite these sudden changes in dietary energy prepartum and postpartum, inflammatory cytokines remained constant, indicating that fat-tailed ewes prioritize redox adaptation over inflammation under nutritional stress and parturition-related metabolic demands. 2026-01-01T00:00:00Z https://accedacris.ulpgc.es/jspui/handle/10553/168362 Título: Profilaxis de la osteoporosis en pacientes tratados con dosis elevadas de glucocorticoide Autores/as: Naranjo Hernández, Antonio; Falcón, Jaime; Plasencia, María Mercedes; de la Nuez, Fidelina; Moreno, Josefina; Ojeda, Soledad Resumen: Background: chronic use of glucocorticoids (GCs) is the most common cause of secondary osteoporosis (OP). However, the prevention of GC-induced OP remains suboptimal despite its inclusion in OP management guidelines. Objective: to analyze the prophylaxis of GC-induced OP at high doses in clinical practice. Methods: the dispensation of GCs and concomitant treatment for OP was analyzed in a district with 2 health care areas. Patients older than 50 years who were dispensed ≥ 90 tablets of prednisone 30 mg through a pharmacy were included. The following data were collected from health records and the electronic pharmacy application: age, sex, reason for using GCs, number of prednisone containers dispensed, bone densitometry performed, and any concomitant use of bisphosphonates or denosumab. Results: a total of 427 patients were included (mean age 66 years M 51 % women). The most frequent body systems involved were respiratory (46 %), cutaneous (10 %), rheumatic (9 %) and neurologic (8 %). OP prophylaxis was dispensed in 59 cases (13.8 %). In the multivariate analysis, prophylaxis was associated with age > 70 years (OR, 4.23; 95 %CI, 2.11-8.49), female sex (OR, 3.15; 95 %CI, 1.47-6.74), having a rheumatic OR, neurologic disease (OR, 5.33; 95 %CI, 2.53-11.23), a bone densitometry assessment (OR, 3.55; 95 %CI, 1.66-7.57) and dispensation of > 120 prednisone tablets from the pharmacy (OR, 2.31; 95 %CI, 1.14-4.70). Conclusion: in our setting, GC-induced OP prophylaxis was definitely suboptimal. Training sessions are needed for doctors who prescribe high doses of GCs, and electronic prescription alerts should be implemented. 2025-01-01T00:00:00Z https://accedacris.ulpgc.es/jspui/handle/10553/168361 Título: Aula Inmersiva De Aprendizaje (AIDA): Experiencia práctica de uso del metaverso en Ciencias de la Salud Autores/as: Rodríguez Florido, Miguel Ángel; Mompeo Corredera,Blanca Rosa; Sosa, C.; Sacchini, Simona; Hernández Flores, Carmen Nieves; Ramírez, J.A.; Castro Alonso, Pedro Luis Resumen: El metaverso ha emergido como un prometedor recurso pedagógico en el ámbito de las Ciencias de la Salud. A través de la realidad virtual y aumentada, esta herramienta permite simular entornos clínicos realistas, facilitando así la adquisición de habilidades prácticas por parte de los estudiantes. En este tra- bajo se presenta el uso práctico de este concepto mediante la implementación de un Aula Inmersiva De Aprendizaje (AIDA) en los laboratorios docentes de la Facultad de Ciencias de la Salud de la Universidad de Las Palmas de Gran Ca- naria. Este aula, configurada como un entorno en realidad virtual que se incor- pora a los laboratorios de prácticas de Anatomía e Histología, representa un contenido en el metaverso en el que grupos de estudiantes pueden interac- cionar de manera colaborativa y realizar actividades de disección y visualización histológica supervisadas por los docentes. Se evaluó la efectividad de esta in- novadora metodología en el aprendizaje de estudiantes de Enfermería y Me- dicina, analizando sus percepciones sobre la utilidad de este entorno virtual en su formación académica. Los resultados obtenidos, basados en un cuestionario aplicado a 240 estudiantes, sugieren que la integración del metaverso en la en- señanza de las Ciencias de la Salud representa un avance significativo en la for- mación de futuros profesionales. 2024-01-01T00:00:00Z https://accedacris.ulpgc.es/jspui/handle/10553/168360 Título: Dosing Strategies for High-Alert Medications in Obese Pediatric Patients: A Systematic Review Autores/as: Hernandez-Gago, Yolanda; Minagorre, Pedro J. Alcala; Sanchez-Hernandez, Jose German; Marrodan, Belen Rodriguez; Hernandez Sabater, Laura; Negrin, Ana Cristina Rodriguez; Rodríguez Suárez, Claudio Alberto Resumen: Background/Objective: Childhood obesity induces physiological changes that alter drug distribution and clearance; however, these patients are often excluded from clinical trials, creating a critical safety gap for high-alert medications (HAM). The Objective was to evaluate HAM dosing strategies and pharmacokinetic (PK) alterations in overweight and obese pediatric patients. Methods: A systematic review was conducted and registered in PROSPERO (CRD42023452126). A search of MEDLINE, EMBASE, Web of Science, and Cochrane CENTRAL (1990-March 2026) identified studies reporting dosing strategies or PK of HAM in obese or overweight pediatric patients. Studies were included if they reported dosing recommendations or PK parameters. Eligible designs comprised prospective and retrospective, randomized and non-randomized, observational (cohort, case-control, and cross-sectional), case series, case reports, and narrative and systematic reviews. Study selection, data extraction, and quality assessment were conducted independently by two reviewers. Methodological quality was assessed using validated tools, and results were synthesized qualitatively. Results: Of 5801 records, 91 studies were included, providing evidence for only 27% of the evaluated HAM. Total body weight (TBW) appeared to be appropriate for insulin and vancomycin, although close monitoring was required. TBW-based dosing was associated with approximately 20% overexposure for enoxaparin, supporting the use of fat-free mass (FFM) or reduced dosing strategies. Increased clearance may justify higher doses for amlodipine and consideration of adult-equivalent dosing for metformin in adolescents. For gentamicin, FFM appeared to be the most appropriate descriptor, while adjusted body weight was used for valproic acid. In anesthetics and sedatives, reduced TBW-based dosing may be considered for propofol, whereas ideal body weight (IBW) or FFM were generally preferred for ketamine and dexmedetomidine. Analgesics such as fentanyl and morphine may require IBW- or FFM-based dosing, and maintenance dosing of paracetamol may require adjustment. Conclusions: Evidence remains limited and heterogeneous, with no standardized dosing approach. Model-informed strategies-such as population PK (PopPK) and physiologically based PK model (PBPK) approaches-may be useful for hypothesis generation and exploring PK variability; however, their clinical applicability is constrained by the limited and heterogeneous evidence base, and they should be considered exploratory. 2026-01-01T00:00:00Z